CD Markers
CD17 / CDw17
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD17, CDw17, Lactosylceramide[title]
CD17 / CDw17
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2013
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD17, CDw17, Lactosylceramide[title]
Table of Contents
Definition / general | Pathophysiology | Clinical features | Uses by pathologists | Positive staining - normalCite this page: Pernick N. CD17 / CDw17. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd17.html. Accessed January 15th, 2021.
Definition / general
- Most abundant glycosphingolipid in neutrophils; NOT a protein
- Also known as lactosylceramide
- "CD17" is also a type of mutation in beta-thalassemia, unrelated to CD markers (Fetal Diagn Ther 2010;27:25)
Pathophysiology
- Defines successive stages in maturation of myeloid cell (Cell Mol Biol Lett 2003;8:911)
- Rapidly and extensively down-modulated on activated granulocytes (J Immunol 1989;142:2784)
- Acts as a lipid second messenger in mediating TNF-alpha, platelet derived growth factor and oxidized LDL-induced phenotypic changes in cells of the vascular wall
- Acts as pattern recognition receptor in innate immunity (Arch Immunol Ther Exp (Warsz) 2013;61:217)
Clinical features
- Elevated levels are present in plasma of patients with familial hypercholesterolemia, and in plaque intima of aorta in patients who died of cardiovascular disease (Proc Natl Acad Sci U S A 2004;101:6490)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Granulocytes, macrophages / monocytes, platelets, basophils, CD19+ B cells and tonsillar dendritic cells
