Stains & CD markers
CD170-179


Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD170 [TI], CD171 or L1, CD172 or SIRPalpha, CD173 or blood group H2, CD174 or Lewis Y antigen, CD175 [TI] or Tn [TI], CD176 or Thomsen-Friedenreich, CD177 or NB1 glycoprotein, CD178, lambda-5[TI] OR VpreB1[TI] OR CD179[TI]

Nat Pernick, M.D.
Page views in 2020: 23
Page views in 2021 to date: 204
Table of Contents
CD170 | CD171 | CD172a | CD173 | CD174 | CD175 | CD176 | CD177 | CD178 | CD179
Cite this page: Pernick N. CD170-179. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd170.html. Accessed October 15th, 2021.
CD170
  • Aka Sialic acid binding IG-like Lectin 5 (SIGLEC5)
  • May function in cell-cell interaction
  • Positive staining - normal: neutrophils
CD171
  • Aka L1
  • Adhesion molecule required for normal neurohistogenesis
  • Mutations cause CRASH (Corpus callosum hypoplasia / agenesis, Retardation, Aphasia, Spastic paraplegia / shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
  • May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, costimulation of T cell activation in vitro
  • Positive staining - normal: postmitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes
CD172a
  • Aka SIRP alpha
  • Adhesion structure
CD173
  • Aka blood group H2
  • Marker of early hematopoiesis
  • Positive staining - normal: CD34+ hematopoietic progenitor cells
  • Negative staining: mature lymphocytes
CD174
  • Aka Lewis Y antigen
  • Marker of early hematopoiesis
  • Positive staining - normal: CD34+ hematopoietic progenitor cells
  • Negative staining: mature lymphocytes
CD175
  • CD175:
    • Aka Tn
    • Simple mucin type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
  • CD175s:
    • Aka Sialyl Tn (STN)
    • Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
    • Presence associated with aggressive tumors
    • High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
    • Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
    • Positive staining - disease: carcinoma
CD176
  • Aka Thomsen-Friedenreich (TF) oncofetal blood group antigen, galactose beta 1-3 N-acetylgalactosamine alpha
  • Occurs in colon cancer and colitis
CD177
  • Aka NB1 glycoprotein
  • Major immunogenic molecule of neutrophil membrane
  • Positive staining - normal: myeloid cells
CD178
  • Aka CD95 ligand, Fas ligand (FasL)
  • Important role in T cell mediated cytotoxicity; induces apoptosis in Fas expressing target cells
  • Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
  • May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
  • Fas-FasL binding triggers apoptosis in lymphocytes
  • Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
  • Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
  • Positive staining - normal: activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
  • Positive staining - tumors: Reed-Sternberg cells of Hodgkin’s lymphoma (nodular sclerosis and mixed cellularity) (Am J Surg Pathol 2001;25:388)
CD179
  • CD179a:
    • Aka VpreB1
    • Associates noncovalently with CD179b to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
  • CD179b:
    • Aka lambda-5
    • Associates noncovalently with CD179a to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
    • Mutations impair B cell development and cause agammaglobulinemia
  • Positive staining - normal: preB cells
Back to top
Image 01 Image 02