CD Markers
CD170-179
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD170 [TI], CD171 or L1, CD172 or SIRPalpha, CD173 or blood group H2, CD174 or Lewis Y antigen, CD175 [TI] or Tn [TI], CD176 or Thomsen-Friedenreich, CD177 or NB1 glycoprotein, CD178, lambda-5[TI] OR VpreB1[TI] OR CD179[TI]
CD170-179
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 14 May 2021
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD170 [TI], CD171 or L1, CD172 or SIRPalpha, CD173 or blood group H2, CD174 or Lewis Y antigen, CD175 [TI] or Tn [TI], CD176 or Thomsen-Friedenreich, CD177 or NB1 glycoprotein, CD178, lambda-5[TI] OR VpreB1[TI] OR CD179[TI]
Cite this page: Pernick N. CD170-179. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd170.html. Accessed June 20th, 2021.
CD170
- Aka Sialic acid binding IG-like Lectin 5 (SIGLEC5)
- May function in cell-cell interaction
- Positive staining - normal: neutrophils
CD171
- Aka L1
- Adhesion molecule required for normal neurohistogenesis
- Mutations cause CRASH (Corpus callosum hypoplasia / agenesis, Retardation, Aphasia, Spastic paraplegia / shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
- May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, costimulation of T cell activation in vitro
- Positive staining - normal: postmitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes
CD173
CD174
CD175
- CD175:
- Aka Tn
- Simple mucin type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
- CD175s:
- Aka Sialyl Tn (STN)
- Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
- Presence associated with aggressive tumors
- High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
- Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
- Positive staining - disease: carcinoma
CD176
CD177
CD178
- Aka CD95 ligand, Fas ligand (FasL)
- Important role in T cell mediated cytotoxicity; induces apoptosis in Fas expressing target cells
- Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
- May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
- Fas-FasL binding triggers apoptosis in lymphocytes
- Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
- Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
- Positive staining - normal: activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
- Positive staining - tumors: Reed-Sternberg cells of Hodgkin’s lymphoma (nodular sclerosis and mixed cellularity) (Am J Surg Pathol 2001;25:388)
CD179
- CD179a:
- Aka VpreB1
- Associates noncovalently with CD179b to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
- CD179b:
- Aka lambda-5
- Associates noncovalently with CD179a to form surrogate light chain as component of preB cell receptor, which plays a critical role in early B cell differentiation
- Mutations impair B cell development and cause agammaglobulinemia
- Positive staining - normal: preB cells
