CD Markers

Topic Completed: 1 February 2002

Minor changes: 12 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD171 or L1

Nat Pernick, M.D.
Page views in 2020: 277
Page views in 2021 to date: 16
Cite this page: Pernick N. CD171. website. Accessed January 15th, 2021.
Definition / general
  • Aka L1
  • Adhesion molecule required for normal neurohistogenesis
  • Mutations cause CRASH (Corpus callosum hypoplasia/agenesis, Retardation, Aphasia, Spastic paraplegia/shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
  • May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, co-stimulation of T-cell activation in vitro
Positive staining - normal
  • Post-mitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes
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