Cite this page: Pernick N. CD171. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd171.html. Accessed January 15th, 2021.
Definition / general
- Aka L1
- Adhesion molecule required for normal neurohistogenesis
- Mutations cause CRASH (Corpus callosum hypoplasia/agenesis, Retardation, Aphasia, Spastic paraplegia/shuffling gait and Hydrocephalus due to stenosis of aqueduct of Sylvius), an X linked neurologic disorder
- May mediate kidney branching morphogenesis, maintenance of lymph node architecture during immune response, co-stimulation of T-cell activation in vitro
Positive staining - normal
- Post-mitotic neurons, glia, epithelial cells (some), lymphoid cells (some), myeloid (some), monocytes