CD Markers
CD175
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD175 [title] or Tn [title]
CD175
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 12 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD175 [title] or Tn [title]
Cite this page: Pernick N. CD175. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd175.html. Accessed January 15th, 2021.
Definition / general
- CD175:
- Aka Tn
- Simple mucin-type carbohydrate antigen produced in the initial steps of mucin biosynthetic pathway, due to aberrant or incomplete glycosylation of mucins
- CD175s:
- Aka Sialyl Tn (STN)
- Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
- Presence associated with aggressive tumors
- High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
- Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease
- CD175s: carcinoma
