CD Markers

Topic Completed: 1 August 2013

Minor changes: 31 August 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD178

Nat Pernick, M.D.
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Cite this page: Pernick N. CD178. website. Accessed January 20th, 2021.
Definition / general
  • Aka CD95 ligand, Fas ligand (FasL)
  • Important role in T cell mediated cytotoxicity; induces apoptosis in Fas-expressing target cells
  • Cells in immune privileged sites (testis, anterior chamber of eye, placenta) constitutively express FasL, which induces apoptosis in Fas-expressing infiltrating T cells, minimizing inflammatory responses that might damage important physiologic functions at these sites
  • May influence interaction of tumor cells with host immune system; theory is that FasL+ tumor cells induce apoptosis in infiltrating Fas+ mononuclear cells
  • Fas-FasL binding triggers apoptosis in lymphocytes
  • Mutations may be related to some cases of Systemic Lupus Erythematosis (SLE)
  • Processed by metalloproteases which cause shedding of extracellular portion into blood (sFas L)
Positive staining - normal
  • Activated and cytotoxic T cells, testis, anterior chamber of eye, placenta; also Sertoli cells, neurons, thyroid epithelial cells
Positive staining - tumors
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