Stains & CD markers
CD180-189


Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD180 or RP105, CD181, CXCR2 stain, CXCR3[title], CD184, CXCR5, CD186

Nat Pernick, M.D.
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Cite this page: Pernick N. CD180-189. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd180.html. Accessed October 24th, 2021.
CD180
  • Also called RP105
  • Regulates B cell recognition of lipopolysaccharide, a membrane constituent of gram-negative bacteria
  • Positive staining - normal: mantle zone and marginal zone B cells (strong), other B cells (weak/negative); peripheral blood monocytes, dendritic cells
CD181
  • Also called CXCR1, IL8Ralpha; previously called CDw128A
  • Chemokine receptor, powerful neutrophil chemotactic factor
  • Positive staining - normal: neutrophils, basophils, T cell subset, monocytes, keratinocytes
  • Positive staining - disease: T cells in allergic rhinitis (J Immunol 2004;172:268)
CD182
  • Also called CXCR2; formerly called CD128b
  • Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
  • Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
  • Interpretation: cytoplasmic staining
  • Uses by pathologists: no significant uses by pathologists
  • Positive staining - normal: mature granulocytes, keratinocytes, neuroendocrine cells, projection neurons (Arch Pathol Lab Med 2000;124:520)
  • Positive staining - disease: carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
  • Negative staining: parathyroid cells; small cell carcinoma of lung / cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma
CD183
  • Also called CXCR3
  • Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
  • CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
  • Positive staining - normal: T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
  • Negative staining: na├»ve T cells in peripheral blood
CD184
  • Also called CXCR4, Stromal cell Derived Factor 1 (SDF1)
  • Receptor for the CXC chemokine SDF-1
  • Also major HIV/SIV co-receptor (with CCR5/CD195)
  • Involved in B cell development, myelopoiesis, cardiac ventricular septum formation, blood vessel formation in GI tract, cerebellar granular cell development
  • Positive staining - normal: all mature blood cells, blood progenitor cells, endothelial and epithelial cells, astrocytes, neurons
CD185
  • Multipass membrane protein of CXC chemokine receptor family
  • Also called CXCR5, BLR1 (Burkitt lymphoma receptor 1)
  • Pathophysiology:
    • Binds to B Lymphocyte Chemoattractant (BLC / CXCL13) (J Exp Med 1998;187:655)
    • Involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
    • Critical for function of follicular helper T (TFH) cells
    • May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
    • May be important for ectopic mucosa associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
    • During HIV1 infection, altered expression of CXCR5 / CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
    • Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
  • Interpretation: cytoplasmic staining
  • Uses by pathologists: no significant uses by pathologists
  • Positive staining - normal: mature B cells
  • Positive staining - disease: Burkitt's lymphoma, mantle cell lymphoma; AIDS-related non-Hodgkin lymphoma (Blood 2009;113:4604, AIDS Res Treat 2010;2010:164586)
CD186
  • No information available
CD187
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD188
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD189
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
Diagrams / tables

Images hosted on other servers:

CD182: inflammatory infiltration

Microscopic (histologic) images

Images hosted on other servers:

CD182: ovarian carcinoma

CD185: chronic H. pylori gastris (left); MALT lymphoma (right)

CD185: AIDS related non-Hodgkin lymphoma

CD185: synovium of non-rheumatoid arthritis (left) and rheumatoid arthritis (right)


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