Pathology Outlines

CD Markers
CD180-189

Topic Completed: 1 February 2002

Minor changes: 14 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD180 or RP105, CD181, CXCR2 stain, CXCR3[title], CD184, CXCR5, CD186

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Page views in 2021 to date: 73

Table of Contents

CD180 | CD181 | CD182 | CD183 | CD184 | CD185 | CD186 | CD187 | CD188 | CD189 | Diagrams / tables | Microscopic (histologic) images

Cite this page: Pernick N. CD180-189. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd180.html. Accessed June 23rd, 2021.

CD180

Also called RP105
Regulates B cell recognition of lipopolysaccharide, a membrane constituent of gram-negative bacteria
Positive staining - normal: mantle zone and marginal zone B cells (strong), other B cells (weak/negative); peripheral blood monocytes, dendritic cells

CD181

Also called CXCR1, IL8Ralpha; previously called CDw128A
Chemokine receptor, powerful neutrophil chemotactic factor
Positive staining - normal: neutrophils, basophils, T cell subset, monocytes, keratinocytes
Positive staining - disease: T cells in allergic rhinitis (J Immunol 2004;172:268)

CD182

Also called CXCR2; formerly called CD128b
Interleukin 8 receptor beta subunit (IL8RB); binds multiple CXC chemokines including IL-8 (CXCL8)
Chemokine receptor, powerful neutrophil chemotactic factor, particularly to sites of inflammation
Interpretation: cytoplasmic staining
Uses by pathologists: no significant uses by pathologists
Positive staining - normal: mature granulocytes, keratinocytes, neuroendocrine cells, projection neurons (Arch Pathol Lab Med 2000;124:520)
Positive staining - disease: carcinoid tumor (classic, atypical, metastatic), pituitary adenoma, pheochromocytoma, medullary carcinoma
Negative staining: parathyroid cells; small cell carcinoma of lung / cervix, large cell lung neuroendocrine carcinoma, Merkel cell carcinoma, neuroblastoma, melanoma

CD183

Also called CXCR3
Receptor for some chemokines; binding of chemokines to CD183 induces integrin activation, cytoskeletal changes and chemotactic migration in inflammation-associated effector T cells
CD183+ T cells detected in inflamed tissues of patients with juvenile rheumatoid arthritis, multiple sclerosis, sarcoidosis, hepatitis C
Positive staining - normal: T cells in inflamed tissue, eosinophils, plasmacytoid dendritic cells, hematopoietic progenitors
Negative staining: naïve T cells in peripheral blood

CD184

Also called CXCR4, Stromal cell Derived Factor 1 (SDF1)
Receptor for the CXC chemokine SDF-1
Also major HIV/SIV co-receptor (with CCR5/CD195)
Involved in B cell development, myelopoiesis, cardiac ventricular septum formation, blood vessel formation in GI tract, cerebellar granular cell development
Positive staining - normal: all mature blood cells, blood progenitor cells, endothelial and epithelial cells, astrocytes, neurons

CD185

Multipass membrane protein of CXC chemokine receptor family
Also called CXCR5, BLR1 (Burkitt lymphoma receptor 1)
Pathophysiology:
- Binds to B Lymphocyte Chemoattractant (BLC / CXCL13) (J Exp Med 1998;187:655)
- Involved in B cell migration into B cell follicles of spleen and Peyer patches (J Immunol 2009;182:2610)
- Critical for function of follicular helper T (TFH) cells
- May have role in survival and maintainance of cardiac structure upon pressure overload by regulating proteoglycans essential for correct collagen assembly (PLoS One 2011;6:e18668)
- May be important for ectopic mucosa associated lymphoid tissue neogenesis in chronic Helicobacter pylori induced inflammation (J Mol Med (Berl) 2010;88:1169)
- During HIV1 infection, altered expression of CXCR5 / CXCL13 may cause B cell dysfunction (Blood 2008;112:4401)
- Upregulated in rheumatoid arthritis synovial tissue and expressed in various cell types (Arthritis Res Ther 2005;7:R217)
Interpretation: cytoplasmic staining
Uses by pathologists: no significant uses by pathologists
Positive staining - normal: mature B cells
Positive staining - disease: Burkitt's lymphoma, mantle cell lymphoma; AIDS-related non-Hodgkin lymphoma (Blood 2009;113:4604, AIDS Res Treat 2010;2010:164586)