CD Markers

Topic Completed: 1 July 2013

Minor changes: 1 October 2020

Copyright: 2002-2021,, Inc.

Related: CD1aCD1bCD1dCD1eCD1-General

Nat Pernick, M.D.
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Cite this page: Pernick N. CD1c. website. Accessed May 8th, 2021.
Definition / general
  • On chromosome 1q22-23 (not MHC linked); non-covalently associated with beta2 microglobulin
  • Mediates the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells (Immunity 2010;33:853)
  • Has the capacity to present a wide repertoire of antigens to reactive T cells (Mol Immunol 2013;55:182, J Biol Chem 2011;286:37692)
  • Expressed on a subset of myeloid dendritic cells; secrete IL10 in response to Escherichia coli (Eur J Immunol 2012;42:1512)
  • Common CD1c antibody is BDCA1
Clinical features
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

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Spleen: marginal zone B cells

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Stomach: H. pylori+ mucosa

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Thyroid gland

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Immature dendritic cells

Positive staining - normal
  • Cortical thymocytes, Langerhans cells (weaker staining than CD1a), immature myeloid dendritic cells (J Clin Invest 2007;117:2517)
  • Subset of normal peripheral B cells, subset of activated T cells
Positive staining - disease
Negative staining
  • Normal B cells
Electron microscopy description
Electron microscopy images

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Found in various cellular locations

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