CD Markers

Topic Completed: 1 July 2013

Minor changes: 1 October 2020

Copyright: 2002-2021,, Inc.

Related: CD1aCD1bCD1cCD1eCD1-General

Nat Pernick, M.D.
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Cite this page: Pernick N. CD1d. website. Accessed May 8th, 2021.
Definition / general
  • CD1d presents lipid antigens to natural killer T (NKT) cells; when activated, NKT cells rapidly produce Th1 and Th2 cytokines, typically represented by interferon gamma and IL4 (Wikipedia: CD1D [Accessed 31 July 2018], OMIM: 188410 [Accessed 31 July 2018])
  • B cells also present lipid antigen to CD1d restricted invariant NKT cells, which contributes to maintaining tolerance in autoimmunity
  • On chromosome 1q22-23 (not MHC linked)
  • Also called R3G1
  • Sole group 2 member of the CD1 family of MHC-like glycoproteins
Diagrams / tables

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Antigen presentation

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Viral evasion of antigen presentation

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Intestinal epithelial CD1d expression

Clinical features
Uses by pathologists
Case reports
  • 6 year old boy with no apparent immunodeficiency who suffered severe life-threatening infection with varicella vaccine virus, with low invariant natural killer T cells and diminished CD1d expression (J Infect Dis 2011;204:1893)
Microscopic (histologic) images

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Cervix: HPV associated lesions

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Lymph node: paracortical dendritic cells (fig 2)

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Placenta: trophoblast

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Skin: scalp

Positive staining - normal
Positive staining - disease
  • Some B and T cell malignancies; keratinocytes in psoriasis
Negative staining
  • Normal B cells
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