CD Markers
CD1e
Copyright: 2002-2021, PathologyOutlines.com, Inc.
Related: CD1a CD1b CD1c CD1d CD1-General
CD1e
Author: Nat Pernick, M.D.
Topic Completed: 1 July 2013
Minor changes: 1 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
Related: CD1a CD1b CD1c CD1d CD1-General
Table of Contents
Definition / general | Clinical features | Uses by pathologists | Positive staining - normalCite this page: Pernick N. CD1e. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd1e.html. Accessed January 15th, 2021.
Definition / general
- Participates in lipid antigen presentation without interacting with T cell receptor; binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens; may positively or negatively affect lipid presentation by CD1b, CD1c, CD1d (Proc Natl Acad Sci USA 2011;108:14228)
- Naturally occurring mutation in CD1e impairs lipid antigen presentation (J Immunol 2008;180:3642)
- Only CD1 protein existing in soluble form in late endosomes of dendritic cells; not expressed on cell surface
- On chromosome 1q22-23 (not MHC linked); non-covalently associated with beta2 microglobulin
Clinical features
- Processes mycobacterial antigen (instead of presenting antigen directly) and may help expand repertoire of glycolipid T cell antigens to optimize the immune response (Science 2005;310:1321, Proc Natl Acad Sci USA 2011;108:13230); presentment is done by CD1b (J Biol Chem 2012;287:31494)
- Initially accumulates in Golgi of immature dendritic cells or transfected cells as a membrane-associated form, then is transported to early and then late endosomes, then is cleaved into a soluble form, which facilitates the processing of glycolipids presented by other CD1 molecules transiting through the same compartments (Biochem J 2009;419:661)
- +6129 A/G gene polymorphisms are associated with multiple sclerosis (Immunol Invest 2010;39:874)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Dendritic cells
