Stains & CD markers
CD200-209


Topic Completed: 1 August 2013

Minor changes: 24 June 2021

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD200, CD201, CD202b, CD203c, CD204, CD205, CD206, CD207, CD208, CD209

Nat Pernick, M.D.
Page views in 2020: 1,490
Page views in 2021 to date: 2,262
Table of Contents
CD200 | CD201 | CD202b | CD203c | CD204 | CD205 | CD206 | CD207 | CD208 | CD209
Cite this page: Pernick N. CD200-209. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd200.html. Accessed October 21st, 2021.
CD200
  • Aka OX2
  • An immunoadhesin that may deliver immunosuppressive signals and regulate autoimmune disorders
  • Inhibitory for macrophage lineage cells
  • Positive staining - normal: follicular dendritic cells, thymocytes, B cells, T cells, neurons, kidney glomeruli, syncytiotrophoblast, endothelial cells
CD201
  • Binds protein C in a calcium-dependent manner
  • Aka Endothelial Protein C Receptor (EPC R), protein C receptor
  • Protein C is a vitamin K dependent enzyme with major role in coagulation of blood; activated when thrombin binds to thrombomodulin on endothelium.
  • Mutations in CD201 and thrombomodulin associated with late fetal loss; similar mutation associated with venous thromboembolism and myocardial infarction
  • Positive staining - normal: endothelial cells (not in liver and kidney)
CD202b
  • Aka Tie2 (Tyrosine kinase with Ig-like loops and Epidermal growth factor homology domains), aka Tek
  • Receptor tyrosine kinase at #9p21, binds to angiopoietin-1
  • May be earliest mammalian endothelial cell lineage marker
  • Involved in vein morphogenesis and communication between endothelial and smooth muscle cells for remodeling and repair of blood vessels
  • Defects associated with inherited venous malformations
  • Positive staining - normal: endothelial cells, hematopoietic cells
CD203c
  • Aka E-NPP3/PDNP3
  • Enzyme that catalyzes hydrolysis of oligonucleotides, nucleoside phosphates, and NAD
  • Positive staining - normal: prostate, uterus, basophils, mast cells, gliomas, myeloid cells
CD204
  • Aka macrophage scavenger receptor 1
  • Plays a role in endocytosis of macromolecules
  • Positive staining - normal: myeloid cells
CD205
  • Aka DEC205
  • Possible antigen-uptake receptor with a role in initiating immune response
  • Positive staining - normal: dendritic cells
CD206
  • Aka macrophage mannose receptor
  • Acts in phagocytosis and pinocytosis of mannose-containing solutes
  • Positive staining - normal: dendritic cells
CD207
  • Aka langerin (Langerhans cell specific c-type lectin)
  • Functions as endocytic receptor
  • Localized to Birbeck granules
  • Mannose binding to this protein may cause antigen internalization into Birbeck granules and access to a nonclassical antigen-processing pathway
  • Positive staining - normal: Langerhans cells (immature dendritic cells of epidermis and mucosa)
CD208
  • Dendritic cell LAMP (DC-Lamp)
  • Indicates dendritic cell maturation
  • Positive staining - normal: dendritic cells
CD209
  • Aka DC-Sign
  • Binds to HIV1 gp120
  • Mediates transient adhesion of dendritic cells with T cells
  • Positive staining - normal: dendritic cells
Back to top
Image 01 Image 02