CD Markers

Topic Completed: 1 May 2014

Minor changes: 2 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD22[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD22. website. Accessed April 17th, 2021.
Definition / general
  • Also called B lymphocyte cell adhesion molecule (BL-CAM), Sialic acid binding immunoglobulin-like lectin / Siglec-2
Clinical features
Uses by pathologists
  • Pan B cell marker; helpful for diagnosis of hairy cell leukemia
  • Aberrant CD22 expression is useful to detect monoclonal B cells of CLL admixed with benign polyclonal B cells (Am J Clin Pathol 2005;123:826)
Microscopic (histologic) images

Images hosted on other servers:
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High grade B cell lymphoma, fig F

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B ALL, fig D

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Burkitt lymphoma, fig D

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Normal tonsil

Positive staining - normal
  • B cells (considered a pan B cell antigen), dendritic cells and basophils
Positive staining - disease
Negative staining
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