Stains & CD markers
CD230-239


Topic Completed: 1 February 2002

Minor changes: 24 June 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD230 or prion protein [title]

Nat Pernick, M.D.
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Table of Contents
CD230 | CD231 | CD232 | CD233 | CD234 | CD235 | CD236 | CD237 | CD238 | CD239
Cite this page: Pernick N. CD230-239. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd230.html. Accessed October 24th, 2021.
CD230
  • Aka prion protein (“PRotein INfectious agent”)
  • Mutations associated with Gerstmann-Straussler disease, Creutzfeldt-Jakob disease (CJD), familial fatal insomnia, which are neurodegenerative conditions transmissible by inoculation or inherited as autosomal dominant disorders
  • Aberrant isoforms can act as an infectious agent in these disorders as well as in kuru and in scrapie in sheep
  • Replication (infectivity) occurs as abnormal protein with conformational change recruits cellular prion and converts it into infective form with same conformational change
  • Positive staining - normal: neurons (nonpathogenic isoform)
  • Reference: OMIM 176640
CD231
  • Aka T cell Acute Lymphoblastic Leukemia Antigen-1 (TALLA-1), TM4SF2, A15
  • Involved in X-linked intellectual disability (Nat Genet 2000;24:167)
  • Positive staining - normal: T cell acute lymphoblastic leukemia, neuroblastoma cells
  • Positive staining - malignant: T cell acute lymphoblastic leukemia, neuroblastoma cells
  • Negative staining: B cells, monocytes
CD232
  • Aka Virus Encoded Semaphoring Protein Receptor (VESP R)
  • May function as an immune modulator during virus infection
CD233
  • Aka band 3
  • Erythrocyte membrane protein that functions as an anion (chloride/bicarbonate) exchanger and attachment site for cytoskeleton (where spectrin/actin bind to membrane lipid bilayer)
  • Truncated form of CD233 is expressed in kidney and involved in acid secretion
  • Mutations cause hereditary spherocytosis or distal renal tubular acidosis (due to defective acid secretion)
  • Other mutations cause novel blood group antigens which form the Diego blood group system
  • Southeast Asian ovalocytosis is due to heterozygous deletions, common where Plasmodium falciparum malaria is endemic, associated with abnormally rigid, stomatocytic erythrocytes, asymptomatic; children are protected against cerebral malaria
  • Positive staining - normal: erythrocyte plasma membrane (strong), basolateral membrane of a-intercalated cells of the distal tubules and collecting ducts of the kidney
  • Negative staining: all other cells
CD234
  • Aka Duffy blood group antigen (Fy glycoprotein); erythrocyte chemokine receptor, Duffy Antigen Receptor for Chemokines (DARC)
  • RBC receptor for Plasmodium vivax, a malarial parasite
  • Negativity associated with sickle cell trait, due to common protection against malaria provided by both traits African-Americans often Duffy negative and resistant to P. vivax malaria
  • Positive staining - normal: endothelial cells of postcapillary venules, Purkinje cells of cerebellum
  • See also Duffy system
CD235
  • Glycophorins A and B are major sialoglycoproteins of the human erythrocyte membrane; contain antigenic determinants for the MN blood group
  • CD235a: also called glycophorin A
  • CD235b: also called glycophorin B
  • CD235ab: also called glycophorin A/B crossreactive antibodies
  • Positive staining - normal: erythroid cells
  • Positive staining - disease: AML-M6
  • Negative staining: AML M0-M5, M7
CD236
  • CD236: also called glycophorin C/D
  • CD236R: also called glycophorin C
    • Regulates mechanical stability of red cells
    • Mutations cause Gerbich and Yus blood group phenotypes
  • Positive staining - normal: erythroid cells
CD237
  • CD Marker not assigned to a set of antibodies as of 20 December 2011
CD238
  • Aka Kell blood group antigen
  • Positive staining - normal: erythroid cells
  • See also Kell group
CD239
  • Aka Lutheran blood group antigen; B-CAM
  • May mediate cell-cell, cell-matrix adhesion, signal transduction
  • Positive staining - normal: erythroid cells
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