CD Markers
CD230-239
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD230 or prion protein [title]
CD230-239
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 14 May 2021
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD230 or prion protein [title]
Cite this page: Pernick N. CD230-239. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd230.html. Accessed June 20th, 2021.
CD230
- Aka prion protein (“PRotein INfectious agent”)
- Mutations associated with Gerstmann-Straussler disease, Creutzfeldt-Jakob disease (CJD), familial fatal insomnia, which are neurodegenerative conditions transmissible by inoculation or inherited as autosomal dominant disorders
- Aberrant isoforms can act as an infectious agent in these disorders as well as in kuru and in scrapie in sheep
- Replication (infectivity) occurs as abnormal protein with conformational change recruits cellular prion and converts it into infective form with same conformational change
- Positive staining - normal: neurons (nonpathogenic isoform)
- Reference: OMIM 176640
CD231
- Aka T cell Acute Lymphoblastic Leukemia Antigen-1 (TALLA-1), TM4SF2, A15
- Involved in X-linked intellectual disability (Nat Genet 2000;24:167)
- Positive staining - normal: T cell acute lymphoblastic leukemia, neuroblastoma cells
- Positive staining - malignant: T cell acute lymphoblastic leukemia, neuroblastoma cells
- Negative staining: B cells, monocytes
CD232
CD233
- Aka band 3
- Erythrocyte membrane protein that functions as an anion (chloride/bicarbonate) exchanger and attachment site for cytoskeleton (where spectrin/actin bind to membrane lipid bilayer)
- Truncated form of CD233 is expressed in kidney and involved in acid secretion
- Mutations cause hereditary spherocytosis or distal renal tubular acidosis (due to defective acid secretion)
- Other mutations cause novel blood group antigens which form the Diego blood group system
- Southeast Asian ovalocytosis is due to heterozygous deletions, common where Plasmodium falciparum malaria is endemic, associated with abnormally rigid, stomatocytic erythrocytes, asymptomatic; children are protected against cerebral malaria
- Positive staining - normal: erythrocyte plasma membrane (strong), basolateral membrane of a-intercalated cells of the distal tubules and collecting ducts of the kidney
- Negative staining: all other cells
CD234
- Aka Duffy blood group antigen (Fy glycoprotein); erythrocyte chemokine receptor, Duffy Antigen Receptor for Chemokines (DARC)
- RBC receptor for Plasmodium vivax, a malarial parasite
- Negativity associated with sickle cell trait, due to common protection against malaria provided by both traits African-Americans often Duffy negative and resistant to P. vivax malaria
- Positive staining - normal: endothelial cells of postcapillary venules, Purkinje cells of cerebellum
- See also Duffy system
CD235
- Glycophorins A and B are major sialoglycoproteins of the human erythrocyte membrane; contain antigenic determinants for the MN blood group
- CD235a: also called glycophorin A
- CD235b: also called glycophorin B
- CD235ab: also called glycophorin A/B crossreactive antibodies
- Positive staining - normal: erythroid cells
- Positive staining - disease: AML-M6
- Negative staining: AML M0-M5, M7
CD236
CD238
- Aka Kell blood group antigen
- Positive staining - normal: erythroid cells
- See also Kell group
