CD Markers
CD230
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD230 or prion protein [title]
CD230
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 13 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD230 or prion protein [title]
Cite this page: Pernick N. CD230. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd230.html. Accessed January 15th, 2021.
Definition / general
- Aka prion protein (“PRotein INfectious agent”)
- Mutations associated with Gerstmann-Straussler disease, Creutzfeldt-Jakob disease (CJD), familial fatal insomnia, which are neurodegenerative conditions transmissible by inoculation or inherited as autosomal dominant disorders
- Aberrant isoforms can act as an infectious agent in these disorders as well as in kuru and in scrapie in sheep
- Replication (infectivity) occurs as abnormal protein with conformational change recruits cellular prion and converts it into infective form with same conformational change
Positive staining - normal
- Neurons (nonpathogenic isoform)
Additional references
