CD Markers
CD233
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD233
CD233
Author: Nat Pernick, M.D.
Topic Completed: 1 August 2013
Minor changes: 13 November 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD233
Cite this page: Pernick N. CD233. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd233.html. Accessed January 15th, 2021.
Definition / general
- Aka band 3
- Erythrocyte membrane protein that functions as an anion (chloride/bicarbonate) exchanger and attachment site for cytoskeleton (where spectrin/actin bind to membrane lipid bilayer)
- Truncated form of CD233 is expressed in kidney and involved in acid secretion
- Mutations cause hereditary spherocytosis or distal renal tubular acidosis (due to defective acid secretion)
- Other mutations cause novel blood group antigens which form the Diego blood group system
- Southeast Asian ovalocytosis is due to heterozygous deletions, common where Plasmodium falciparum malaria is endemic, associated with abnormally rigid, stomatocytic erythrocytes, asymptomatic; children are protected against cerebral malaria
Positive staining - normal
- Erythrocyte plasma membrane (strong), basolateral membrane of a-intercalated cells of the distal tubules and collecting ducts of the kidney
Negative staining
- All other cells
