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Cite this page: Pernick N. CD240-249. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd240.html. Accessed June 23rd, 2021.
CD240CE
  • Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens; encodes RhC and RhE antigens on a single polypeptide
  • On #1p36.11 adjacent to RH D gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions and missense mutations
  • Rh antigens are carried by an oligomer of two major erythroid specific polypeptides, the Rh (D and CcEe) proteins and the RhAG glycoprotein
  • Discrepant or doubtful serologic results can be resolved by sequence specific primer (PCR SSP) technique (Transfusion 2007;47:54S)
  • Rarely causes hemolytic disease of newborn (Transfus Med 2000;10:305)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • References: Blood 2000;95:375, OMIM 111700
CD240D
  • Also called RH30 D, Rh blood group D blood group antigen; is major antigen of the Rh system
  • On #1p36.11 adjacent to RHCE gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions and missense mutations
  • Weak D, formerly called D(u), occurs in 0.2 to 1% of whites
  • Individuals are classified as Rh positive or negative based on presence or absence of highly immunogenic D antigen on red cell surface
  • May have arisen historically by duplication of RHCE gene (Blood 2002;99:2272)
  • Discrepant or doubtful serologic results can be resolved by sequence specific primer (PCR SSP) technique (Transfusion 2007;47:54S)
  • Hemolytic disease of fetus and newborn: usually due to Rh negative woman whose partner is Rh+ or heterozygous and fetus is Rh+; woman has preexisting anti-RhD antibodies that cross placenta and harm fetus (Immunohematol 2006;22:188)
  • Can use maternal plasma in alloimmunized pregnancies to determine fetal RhD status or for RHD and RHCE genotyping (Fetal Diagn Ther 2006;21:404, Prenat Diagn 2005;25:1079)
  • Rh positive mothers may rarely (0.15%) develop new antibodies (other than anti-RHD) in third trimester but no clinical significance (J Matern Fetal Neonatal Med 2007;20:59)
  • Having Rh negative mother may be risk factor for autistic children, due to use of mercury containing Rho-immune globulin (J Matern Fetal Neonatal Med 2007;20:385)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • References: OMIM 111680, Wikipedia, eMedicine (Rh incompatibility)
CD240DCE
  • Rh30D / CE crossreactive monoclonal antibodies
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells of normal Rh types
  • Negative staining: Rh null erythrocytes
CD241
CD242
  • Also called intercellular adhesion molecule 4 (ICAM-4), Landsteiner-Wiener (LW) blood group protein
  • Discovered with antibody raised in guinea pigs injected with the cells of rhesus monkeys but Rh designation had already been taken
  • Binds to CD11a / CD18, CD11b / CD18 and CD11c / CD18 (Blood 2007;109:802)
  • May be critical in erythroblastic island formation, where erythroid progenitors differentiate (Blood 2006;108:2064)
  • May be ligand for platelet activated alpha IIb beta 3 integrin (J Biol Chem 2003;278:4892)
  • In sickle cell disease, contributes to red cell endothelial cell adhesion and vasoocclusion (Transfus Clin Biol 2006;13:44)
  • Uses by pathologists: no significant clinical use by pathologists
  • Positive staining - normal: erythroid cells
  • References: OMIM 111250
CD243
CD244
CD245
  • Also called p220 / 240
  • Very little information is available for CD245 directly; appears to be identical to NPAT (nuclear protein, ataxia-telangiectasia locus)
  • NPAT links S phase cyclin E / Cdk2 kinase activity to replication dependent histone gene transcription (Biochemistry 2006;45:15915, Mol Cell Biol 2005;25:6140)
  • Uses by pathologists: no significant clinical use by pathologists
  • Positive staining - normal: T cells (some), other white blood cells with varying intensity
CD246
CD247
CD248
CD249
Diagrams / tables

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CD247: T cell activation

Microscopic (histologic) images

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CD247: normal expression

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CD247: reduced expression

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CD248: IHC detection of FB5 antigen

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