CD Markers
CD240 and variants


Topic Completed: 1 August 2013

Minor changes: 30 December 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: Rh Cc and Ee blood group antigens

Nat Pernick, M.D.
Page views in 2020: 73
Page views in 2021 to date: 3
Table of Contents
CD240CE | CD240D | CD240DCE
Cite this page: Pernick N. CD240 and variants . PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd240.html. Accessed January 15th, 2021.
CD240CE
  • Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens; encodes RhC and RhE antigens on a single polypeptide
  • On #1p36.11 adjacent to RH D gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions, and missense mutations
  • Rh antigens are carried by an oligomer of two major erythroid specific polypeptides, the Rh (D and CcEe) proteins and the RhAG glycoprotein; Rh proteins form a core complex critical to structure of erythrocyte membrane (Blood Rev 2006;20:93); may play a role in ammonia transport (J Biol Chem 2002;277:12499, but see Transfus Clin Biol 2006;13:132)
  • Discrepant or doubtful serologic results can be resolved by PCR-SSP technique (Transfusion 2007;47:54S)
  • Rarely causes hemolytic disease of newborn (Transfus Med 2000;10:305)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • References: Blood Group Antigen Gene Mutation Database, Blood 2000;95:375, OMIM 111700
CD240D
  • Also called RH30 D, Rh blood group D blood group antigen; is major antigen of the Rh system
  • On #1p36.11 adjacent to RHCE gene
  • Rh (rhesus) blood group system is second most clinically significant blood group after ABO; is most polymorphic blood group, with variations due to deletions, gene conversions, and missense mutations
  • Weak D, formerly called D(u), occurs in 0.2 to 1% of whites; exhibits reduced expression of D antigen (Blood 1999;93:385); should not be labeled as Rh negative (Curr Opin Hematol 2006;13:476)
  • Individuals are classified as Rh positive or negative based on presence or absence of highly immunogenic D antigen on red cell surface
  • May have arisen historically by duplication of RHCE gene (Blood 2002;99:2272)
  • Discrepant or doubtful serologic results can be resolved by PCR-SSP technique (Transfusion 2007;47:54S)
  • Hemolytic disease of fetus and newborn: usually due to Rh negative woman whose partner is Rh+ or heterozygous and fetus is Rh+; woman has preexisting anti-RhD antibodies that cross placenta and harm fetus (Immunohematol 2006;22:188)
  • Can use maternal plasma in alloimmunized pregnancies to determine fetal RhD status (Fetal Diagn Ther 2006;21:404), or for RHD and RHCE genotyping (Prenat Diagn 2005;25:1079); genotyping from amniotic fluid or chorionic villi sampling was performed in past, but is more invasive (N Engl J Med 1998;339:1734, Clin Exp Med 2002;2:77)
  • Rh positive mothers may rarely (0.15%) develop new antibodies (other than anti-RHD) in third trimester, but no clinical significance (J Matern Fetal Neonatal Med 2007;20:59)
  • Having Rh negative mother may be risk factor for autistic children, due to use of mercury containing Rho-immune globulin (J Matern Fetal Neonatal Med 2007;20:385)
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells
  • OMIM 111680, Wikipedia, eMedicine (Rh incompatibility)
CD240DCE
  • Rh30D/CE crossreactive monoclonal antibodies
  • Uses by pathologists: blood typing
  • Positive staining - normal: erythroid cells of normal Rh types
  • Negative staining: Rh null erythrocytes
Back to top
Image 01 Image 02