CD Markers

Topic Completed: 1 February 2002

Minor changes: 16 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: ICAM-4 or LW blood group protein

Nat Pernick, M.D.
Page views in 2020: 29
Cite this page: Pernick N. CD242. website. Accessed January 16th, 2021.
Definition / general
  • Also called intercellular adhesion molecule 4 (ICAM-4), Landsteiner-Wiener (LW) blood group protein
  • Discovered with antibody raised in guinea pigs injected with the cells of rhesus monkeys, but Rh designation had already been taken
  • Binds to CD11a/CD18, CD11b/CD18 and CD11c/CD18 (Blood 2007;109:802)
  • May be critical in erythroblastic island formation, where erythroid progenitors differentiate (Blood 2006;108:2064)
  • May be ligand for platelet-activated alpha IIb beta 3 integrin (J Biol Chem 2003;278:4892)
  • In sickle cell disease, contributes to red cell-endothelial cell adhesion and vasoocclusion (Transfus Clin Biol 2006;13:44)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Erythroid cells
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