CD Markers
CD242
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: ICAM-4 or LW blood group protein
CD242
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 16 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: ICAM-4 or LW blood group protein
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Additional referencesCite this page: Pernick N. CD242. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd242.html. Accessed January 16th, 2021.
Definition / general
- Also called intercellular adhesion molecule 4 (ICAM-4), Landsteiner-Wiener (LW) blood group protein
- Discovered with antibody raised in guinea pigs injected with the cells of rhesus monkeys, but Rh designation had already been taken
- Binds to CD11a/CD18, CD11b/CD18 and CD11c/CD18 (Blood 2007;109:802)
- May be critical in erythroblastic island formation, where erythroid progenitors differentiate (Blood 2006;108:2064)
- May be ligand for platelet-activated alpha IIb beta 3 integrin (J Biol Chem 2003;278:4892)
- In sickle cell disease, contributes to red cell-endothelial cell adhesion and vasoocclusion (Transfus Clin Biol 2006;13:44)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Erythroid cells
Additional references
