CD Markers
CD244
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD244 or NK cell receptor 2B4
CD244
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 16 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD244 or NK cell receptor 2B4
Table of Contents
Definition / general | Diagrams / tables | Uses by pathologists | Positive staining - normal | Additional referencesCite this page: Pernick N. CD244. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd244.html. Accessed January 15th, 2021.
Definition / general
- Also called Natural Killer cell receptor 2B4
- Regulates NK and T cell function in multiple ways (J Immunol 2005;175:2045)
- Coexpression of 2B4 and CD160 defines a CD8+ T lymphocyte subpopulation with high cytolytic effector activity (Eur J Immunol 2006;36:2359)
- Binds to CD48 (J Immunol 2006;176:4646), and CD244-CD48 interactions prevent NK cells from killing each other (Blood 2007;110:2020)
- Functional changes are associated with X linked lymphoproliferative disease (J Exp Med 2000;192:337, J Immunol 2000;165:2932)
Diagrams / tables
Images hosted on other servers:
NK cell receptors
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- NK cells, CD8+ T cells, monocytes and basophils (Eur J Immunol 1999;29:1676), eosinophils (J Immunol 2005;174:110), spleen (Tissue Antigens 1999;54:27)
Additional references
