CD Markers
CD247
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD247 or T cell receptor zeta chain [title]
CD247
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2014
Minor changes: 16 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD247 or T cell receptor zeta chain [title]
Table of Contents
Definition / general | Diagrams / tables | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Additional referencesCite this page: Pernick N. CD247. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd247.html. Accessed January 15th, 2021.
Definition / general
- Also called T cell receptor zeta chain
- Forms T cell-CD3 receptor complex with TCR alpha/beta and gamma/delta heterodimers and CD3-gamma, delta and epsilon (Proc Natl Acad Sci USA 1988;85:9709)
- Couples antigen recognition to several intracellular signal transduction pathways; low expression causes impaired immune response
- Low expression in tumor infiltrating T cells in various disorders - cancer of kidney (Cancer Invest 2004;22:871) and stomach (Cancer 2002;94:1437), Hodgkin’s lymphoma (Blood 1996;88:236); also active tuberculosis (J Infect Dis 2006;194:1385), systemic lupus erythematosus (J Immunol 2002;169:6048, Adv Med Sci 2006;51:181), normal pregnancy but not preeclampsia (Am J Obstet Gynecol 2003;189:843)
- Defects cause primary T-cell immunodeficiency (OMIM 610163)
Diagrams / tables
Images hosted on other servers:
T cell activation
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Gastric carcinoma intratumoral lymphocytes compared to CD3 epsilon (fig A):
Normal expression
(fig B)
Reduced expression
(fig B)
Positive staining - normal
- T cells
Additional references
