CD Markers
CD248
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD248 or endosialin or TEM1
CD248
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2014
Minor changes: 16 November 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD248 or endosialin or TEM1
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Additional referencesCite this page: Pernick N. CD248. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd248.html. Accessed January 16th, 2021.
Definition / general
- Also called endosialin, tumor endothelial marker 1 (TEM1)
- Cell surface glycoprotein associated with tumors - traditionally thought present in vascular endothelial cells (Proc Natl Acad Sci USA 1992;89:10832, J Biol Chem 2001;276:7408), but may actually be marker of stromal fibroblasts (FEBS Lett 2005;579:2569)
- Not present (or weak) in non-tumor associated endothelium
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Normal colon and colorectal carcinoma (see TEM1)
IHC detection of FB5 antigen
Positive staining - normal
- Endometrium; embryos (Cancer Res 2001;61:6649), fibroblasts and pericytes during lymphoid tissue development (FEBS Lett 2007;581:3550); RNA at low/moderate levels in many organs
Positive staining - disease
- MFH and other sarcomas, some capillaries and fibroblasts in carcinomas; endothelium of high grade brain tumors (J Neuropathol Exp Neurol 2004;63:1274); RNA at low/moderate levels in carcinomas (Cancer Immun 2005;5:10)
Additional references
