CD Markers
CD25


Topic Completed: 1 July 2013

Minor changes: 2 October 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD25[TI] review[ptyp]


Nat Pernick, M.D.
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Cite this page: Pernick N. CD25. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd25.html. Accessed January 17th, 2021.
Definition / general
  • Marker for hairy cell leukemia and systemic mastocytosis
Terminology
  • Also called IL-2 receptor alpha chain, IL2RA and TAC antigen (OMIM 147730)
Pathophysiology
Diagrams / tables

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Development of CD4+ CD25+ T cells

Clinical features
Uses by pathologists
Microscopic (histologic) images

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HTLV1+ adult T cell leukemia / lymphoma

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Mastocytosis

Positive staining - normal
  • Activated B and T cells, macrophages, osteoblasts; some thymocytes, some myeloid precursors and some oligodendocytes; basophils have dim staining by flow cytometry (Arch Pathol Lab Med 2008;132:813)
Positive staining - disease
Negative staining
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