CD Markers

Topic Completed: 1 September 2014

Minor changes: 2 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD29[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD29. website. Accessed January 15th, 2021.
Definition / general
  • Also called glycoprotein IIa (GP IIa), integrin beta-1 (ITGB1), fibronectin receptor beta subunit, VLA (CD49) beta chain
  • Common beta subunit of integrins VLA1 to VLA6, which are also composed of alpha subunits alpha 1 to alpha 6 (CD49a-f)
  • Combines with CD49a to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
  • Involved in lymphocyte and endothelial adhesion; important for lymphocyte trafficking and transvascular migration
  • Promotes or inhibits apoptosis, depending on the ligands and apoptotic insults (Cancer Res 2003;63:8302)
  • May help define neural lineage differentiation of stem cells (Stem Cells 2009;27:2928)
Uses by pathologists
  • Myoepithelial marker, although established markers (SMA, CD10, p63, S100, maspin, calponin, GFAP, smooth muscle myosin) are more commonly used
Microscopic (histologic) images

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Lung cancer

Positive staining - normal
  • Fibroblasts, platelets, T cells, monocytes, granulocytes (low), mast cells, endothelial cells and myoepithelium; also other diverse cell types
Positive staining - disease
Negative staining
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