CD Markers
CD29
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD29[title]
CD29
Author: Nat Pernick, M.D.
Topic Completed: 1 September 2014
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD29[title]
Table of Contents
Definition / general | Terminology | Pathophysiology | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD29. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd29.html. Accessed January 15th, 2021.
Definition / general
- Integrin component that mediates adhesion and is involved in homing to sites of inflammation
- References: OMIM #135630, Wikipedia)
- Cell Biochem Biophys 2014;70:601
Terminology
- Also called glycoprotein IIa (GP IIa), integrin beta-1 (ITGB1), fibronectin receptor beta subunit, VLA (CD49) beta chain
Pathophysiology
- Common beta subunit of integrins VLA1 to VLA6, which are also composed of alpha subunits alpha 1 to alpha 6 (CD49a-f)
- Combines with CD49a to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
- Involved in lymphocyte and endothelial adhesion; important for lymphocyte trafficking and transvascular migration
- Promotes or inhibits apoptosis, depending on the ligands and apoptotic insults (Cancer Res 2003;63:8302)
- May help define neural lineage differentiation of stem cells (Stem Cells 2009;27:2928)
Uses by pathologists
- Myoepithelial marker, although established markers (SMA, CD10, p63, S100, maspin, calponin, GFAP, smooth muscle myosin) are more commonly used
Microscopic (histologic) images
Images hosted on other servers:
Lung cancer
Positive staining - normal
- Fibroblasts, platelets, T cells, monocytes, granulocytes (low), mast cells, endothelial cells and myoepithelium; also other diverse cell types
Positive staining - disease
- Bile duct epithelium in alcoholic liver disease (16%, Arch Pathol Lab Med 1999;123:411)
- Breast metaplastic carcinoma (90%, Am J Surg Pathol 2005;29:347)
- Breast sarcoma NOS if CD10+ (43%, Am J Surg Pathol 2006;30:450)
- Liver cirrhosis and hepatocellular carcinoma (Zhonghua Gan Zang Bing Za Zhi 2010;18:353)
- Lung cancer (PLoS One 2013;8:e55714)
- Myeloma in bone marrow (Br J Haematol 2002;119:70)
- T cells in asthma (Pol Arch Med Wewn 2012;122:585)
- Trophoblasts in malignant gestational trophoblastic disease (Int J Gynecol Cancer 2013;23:749)
Negative staining
- Red blood cells, spermatogonia (Syst Biol Reprod Med 2013;59:233)
- Intravascular lymphomatosis (Hum Pathol 2000;31:220)
