Stains & CD markers

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Last staff update: 10 June 2022

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PubMed Search: CD30 [title], CD32 [title], CD35 [title], CD36 [title], CD37 [title], CD39 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD30-39. website. Accessed May 19th, 2024.
  • Scavenger receptor with numerous physiologic functions
  • Also known as platelet GPIV or GPIIIb, fatty acid translocase (FAT)
  • Pathophysiology:
    • Numerous potential physiologic functions (see Clinical Features below)
    • Serves as a scavenger receptor for oxidized phospholipids, apoptotic cells and certain microbial pathogens (Trans Am Clin Climatol Assoc 2010;121:206)
    • Receptor for thrombospondin, collagen, oxidized LDL
    • Gives rise to Naka antigen
  • Clinical features:
    • Associated with platelet disorders:
      • Acts as cell adhesion molecule in platelet adhesion and aggregation, platelet monocyte and platelet tumor cell interactions
      • CD36 isoantibody may cause:
      • CD36 deficiency causes platelet glycoprotein IV deficiency (OMIM: 608404 [Accessed 6 May 2021])
        • More common in Asians and Africans
        • Divided into 2 subgroups
        • Type I is characterized by platelets and monocytes / macrophages exhibiting complete CD36 deficiency
        • Type II lacks the surface expression of CD36 in platelets but expression in monocytes / macrophages is near normal
      • CD36 deficiency is associated with hyperlipidemia, insulin resistance and mild hypertension (Mol Cell Biochem 2007;299:19)
    • Associated with atherosclerosis:
      • Scavenger receptor for oxidized LDL and shed photoreceptor outer segments (Atherosclerosis 2006;184:15)
      • Also transports long chain fatty acids
      • Upregulated in familial combined hyperlipidemia (FASEB J 2005;19:2063)
      • Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7
      • CD36 may be taste receptor for fatty acids (J Clin Invest 2005;115:2965)
    • Associated with malaria:
      • Site of cytoadherence of Plasmodium falciparum infected erythrocytes to microvascular endothelial cells
      • CD36 deficiency is frequent in sub Saharan Africa and Asia and is associated surprisingly with susceptibility to severe cerebral malaria
    • Associated with Alzheimer’s disease:
      • May mediate binding to fibrillar beta amyloid
      • Present in microglia and endothelium in Alzheimer's disease
      • Low levels on peripheral blood leukocytes in Alzheimer patients (Neurobiol Aging 2007;28:515)
  • Positive staining - normal:
    • Platelets, monocytes, macrophages, basophils, endothelial cells, early erythroid cells, megakaryocytes
    • Also adipose tissue, breast epithelial cells, cardiac muscle, Sertoli cells of testis (elderly men and those with hypospermatogenesis), skeletal muscle, splenic cells (Hum Pathol 2004;35:34)
  • Positive staining - disease:
  • Negative staining: AML M0 - M2 (usually), AML M3 (Am J Clin Path 1998;109:211)
  • References: OMIM: 173510 [Accessed 6 May 2021], Wikipedia: CD36 [Accessed 6 May 2021]
  • Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151)
  • Regulates T cell proliferation (J Immunol 2004;172:2953)
  • Clinical features: inhibits IgA responses and regulates the anti-fungal immune response (PLoS Pathog 2009;5:e1000338)
  • No significant clinical use by pathologists
  • Positive staining - normal: B cells, T cells (low), neutrophils (low), monocytes (low), macrophages, dendritic cells
  • Positive staining - disease: most B cell lymphomas, some T cell lymphomas (Leukemia 1994;8:1864)
  • Negative staining: NK cells, platelets, erythrocytes, plasma cells; plasma cell neoplasms, pre-B-ALL (or low)
  • Reference: OMIM: 151523 [Accessed 6 May 2021]
Diagrams / tables

Images hosted on other servers:
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CD36 and macrophage phagocytosis

Microscopic (histologic) images

Case #81
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CD35: follicular dendritic cell tumor

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CD35: liver mass

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CD39: donor liver

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