CD Markers

Topic Completed: 1 January 2011

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD32 [title]

Nat Pernick, M.D.
Page views in 2020: 127
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Cite this page: Pernick N. CD32. website. Accessed January 15th, 2021.
Definition / general
  • Low affinity receptor to the Fc region of IgG
  • Low affinity receptor on white blood cells (see below) that binds to the Fc region of IgG immune complexes to remove foreign antigens
Clinical features
Uses by pathologists
  • Preincubation with CD16/CD32 antibodies is commonly used to prevent nonspecific binding
  • No significant clinical use by pathologists
Positive staining - normal
  • CD32a: Monocytes, macrophages; B cells, basophils, eosinophils, granulocytes, NK cells, plasma cells (some), platelets
  • CD32b: Most broadly distributed Fc receptor; monocytes / macrophages; also basophils, B cells eosinophils, Langerhans cells, neutrophils, placenta endothelial cells, platelets; not NK cells
  • CD32c: Monocytes, macrophages, neutrophils, NK cells
Positive staining - disease
  • Follicular lymphoma, histiocytic sarcoma
Negative staining
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