CD Markers
CD32
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD32 [title]
CD32
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2011
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD32 [title]
Table of Contents
Definition / general | Terminology | Pathophysiology | Clinical features | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD32. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd32.html. Accessed January 15th, 2021.
Definition / general
- Low affinity receptor to the Fc region of IgG
Terminology
- Also called Fc gamma RII
- Subtyped as Fc gamma RIIa (OMIM 146790), RIIb (OMIM 604590) and RIIc (OMIM 612169)
Pathophysiology
- Low affinity receptor on white blood cells (see below) that binds to the Fc region of IgG immune complexes to remove foreign antigens
Clinical features
- Polymorphisms affects incidence or severity of some diseases, including antiphospholipid syndrome (Arthritis Rheum 2003;48:1930), IgA nephropathy (Nephrol Dial Transplant 2005;20:2439), malaria (Am J Trop Med Hyg 2003;69:565), myasthenia gravis (J Neuroimmunol 2003;144:143), onchocerciasis (Am J Trop Med Hyg 2007;77:1074), peripheral atherosclerosis (Thromb Haemost 2004;92:1273), rheumatic fever (Clin Biochem 2004;37:925) and systemic lupus erythematosus (Arthritis Rheum 2002;46:1563)
- In dendritic cells, CD32a is considered an activating isoform and CD32b an inhibitory isoform; the balance between these receptors establishes a threshold of activation and enables immune complexes to mediate opposing effects on dendritic cell maturation and function (J Clin Invest 2005;115:2914)
Uses by pathologists
- Preincubation with CD16/CD32 antibodies is commonly used to prevent nonspecific binding
- No significant clinical use by pathologists
Positive staining - normal
- CD32a: Monocytes, macrophages; B cells, basophils, eosinophils, granulocytes, NK cells, plasma cells (some), platelets
- CD32b: Most broadly distributed Fc receptor; monocytes / macrophages; also basophils, B cells eosinophils, Langerhans cells, neutrophils, placenta endothelial cells, platelets; not NK cells
- CD32c: Monocytes, macrophages, neutrophils, NK cells
Positive staining - disease
- Follicular lymphoma, histiocytic sarcoma
Negative staining
- T cells (usually, Immunology 1997;90:109)
