CD Markers

Topic Completed: 1 January 2011

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD35 [title]

Nat Pernick, M.D.
Page views in 2020: 1,445
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Cite this page: Pernick N. CD35. website. Accessed May 6th, 2021.
Definition / general
  • Dendritic cell marker
  • Mediates cellular binding of particles and immune complexes that have activated complement
  • Also called erythrocyte complement receptor 1 (CR1), C3b and C4b receptor
  • Binds immune complexes coated with C3b or C4b and mediates their transport to and removal by the fixed phagocyte systems of the spleen and liver
  • Cofactor for specific proteolytic cleavage of C3b and C4b by plasma serine protease factor I, which limits complement activation and produces ligands for other complement receptors
  • The Knops, McCoy, Swain-Langley, and York blood group antigens are located on CD35 (Blood Group Antigen Gene Mutation Database)
  • Follicular dendritic cells form a reticular network in the lymphoid follicle necessary to retain and present native antigens (in the form of antigen-antibody immune complexes) to B cells during the secondary immune response
  • CD21, CD23 and CD35 are dendritic cell markers
Clinical features
Uses by pathologists
Microscopic (histologic) images

Case #81
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Follicular dendritic cell tumor

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Liver mass

Positive staining - normal
  • Follicular dendritic cells, erythrocytes
  • Basophils, eosinophils, granulocytes, monocytes, macrophages (some), B cells, T cells (10%), NK cell subset, some astrocytes
Positive staining - disease
Negative staining
Additional references
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