CD Markers
CD354 (TREM1)

Topic Completed: 1 April 2014

Minor changes: 19 September 2019

Copyright: (c) 2003-2018,, Inc.

PubMed Search: TREM1

Nat Pernick, M.D.
Page views in 2019: 47
Page views in 2020 to date: 26
Cite this page: Pernick N. CD354 (TREM1). website. Accessed June 2nd, 2020.
Definition / general
  • Triggering REceptor on Myeloid cells; member of Ig superfamily
  • sTREM1: soluble levels of TREM1
  • Part of family of immune sensors which signal innate immune system and amplifies immune responses that promote pro-inflammatory cytokine production; neutrophils are major source of TREM1
  • TREM1 is an activating receptor and requires association with transmembrane adapter molecule DAP12 (DNAX-associated protein 12) for cell signaling (PLoS One 2013;8:e82498, J Leukoc Biol 2013;93:209)
Pathophysiology / etiology
  • TREM1 and MMPs orchestrate an "adaptive" form of innate immunity by modulating the monocyte response to endotoxin (J Leukoc Biol 2012;91:933)
  • Dendritic cells: TREM1 induction by hypoxic microenvironment activates immature dendritic cells and regulates Th1 cell trafficking (Eur J Immunol 2013;43:949)
Clinical features
Uses by pathologists
Microscopic (histologic) images

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Positive staining - normal
  • Myeloid cells
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