CD Markers
CD37
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD37 [title]
CD37
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2011
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD37 [title]
Table of Contents
Definition / general | Clinical features | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD37. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd37.html. Accessed January 15th, 2021.
Definition / general
- Member of tetraspanin family (members have 4 hydrophobic domains, others are CD9, CD53, CD63, CD81, CD82 and CD151)
- Regulates T cell proliferation (J Immunol 2004;172:2953)
Clinical features
- Inhibits IgA responses and regulates the anti-fungal immune response (PLoS Pathog 2009;5:e1000338)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- B cells, T cells (low), neutrophils (low), monocytes (low), macrophages, dendritic cells
Positive staining - disease
- Most B cell lymphomas (Leukemia 1994;8:1864), some T cell lymphomas
Negative staining
- NK cells, platelets, erythrocytes, plasma cells
- Plasma cell neoplasms, preB-ALL (or low)
Additional references
