CD Markers
CD41
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD41
CD41
Author: Nat Pernick, M.D.
Topic Completed: 1 January 2011
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD41
Table of Contents
Definition / general | Terminology | Pathophysiology | Clinical features | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative staining | Additional referencesCite this page: Pernick N. CD41. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd41.html. Accessed January 20th, 2021.
Definition / general
- Platelet glycoprotein IIb, important for platelet aggregation
Terminology
- Also called platelet glycoprotein IIb, GPIIb, platelet fibrinogen receptor alpha subunit
Pathophysiology
- Gene encodes integrin alpha chain 2b, which undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a fibronectin receptor expressed in platelets, which is crucial for platelet aggregation through binding of soluble fibrinogen
- GP IIb/IIIa is also a receptor for fibrinogen, plasminogen, prothrombin, thrombosponin, vitronectin and von Willebrand factor
- Recognizes the sequence R-G-D in a wide array of ligands
- Downregulated by factor XIII and calpain (J Biol Chem 2004;279:30697)
Clinical features
- Mutations cause Glanzmann thrombasthenia (MIM 273800), with a tendency to bleed for prolonged periods following injury
Uses by pathologists
- Identify platelets or megakaryocytes (marker is specific)
- Isolate platelets (Cytometry A 2005;65:84)
- Confirm diagnosis of AML-M7
- Diagnose Glanzmann thrombasthenia
Positive staining - normal
- Platelets, megakaryocytes, hematopoietic progenitor cells (erythroid, myeloid, megakaryocytes, Br J Haematol 1999;105:1044, Development 2002;129:2003), mast cells (Exp Hematol 2005;33:403)
Positive staining - disease
- AML M7, blasts in transient myeloproliferative disorder (Am J Clin Pathol 2001;116:204)
Negative staining
- AML M0 to M6
Additional references
