CD Markers

Topic Completed: 1 January 2011

Minor changes: 2 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD41

Nat Pernick, M.D.
Page views in 2020: 1,471
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Cite this page: Pernick N. CD41. website. Accessed January 20th, 2021.
Definition / general
  • Platelet glycoprotein IIb, important for platelet aggregation
  • Also called platelet glycoprotein IIb, GPIIb, platelet fibrinogen receptor alpha subunit
  • Gene encodes integrin alpha chain 2b, which undergoes post-translational cleavage to yield disulfide linked light and heavy chains which join with integrin beta3 (CD61) to form a fibronectin receptor expressed in platelets, which is crucial for platelet aggregation through binding of soluble fibrinogen
  • GP IIb/IIIa is also a receptor for fibrinogen, plasminogen, prothrombin, thrombosponin, vitronectin and von Willebrand factor
  • Recognizes the sequence R-G-D in a wide array of ligands
  • Downregulated by factor XIII and calpain (J Biol Chem 2004;279:30697)
Clinical features
  • Mutations cause Glanzmann thrombasthenia (MIM 273800), with a tendency to bleed for prolonged periods following injury
Uses by pathologists
  • Identify platelets or megakaryocytes (marker is specific)
  • Isolate platelets (Cytometry A 2005;65:84)
  • Confirm diagnosis of AML-M7
  • Diagnose Glanzmann thrombasthenia
Positive staining - normal
Positive staining - disease
Negative staining
  • AML M0 to M6
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