CD Markers
CD42a
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD42 [title]
Related: CD42b, CD42c, CD42d
CD42a
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2010
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD42 [title]
Related: CD42b, CD42c, CD42d
Table of Contents
Definition / general | Diagrams / tables | Pathophysiology | Uses by pathologists | Positive staining - normal | Negative stainingCite this page: Pernick N. CD42a. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd42a.html. Accessed January 15th, 2021.
Definition / general
- CD42a-d complex is receptor for von Willebrand factor and thrombin
- Also called platelet glycoprotein GPIX, GP9
- Absence of CD42 complex (mutations in CD42a-c) causes Bernard-Soulier syndrome (giant platelet syndrome, OMIM #231200), a bleeding disorder with thrombocytopenia, prolonged bleeding time and giant platelets
- OMIM #173515
Diagrams / tables
Images hosted on other servers:
CD42a-d complex
Pathophysiology
- CD42a-d complex is receptor for von Willebrand factor and thrombin
- This complex mediates adhesion of platelets to subendothelial matrices that are exposed in damaged endothelium and amplifies platelet response to thrombin
- GP-IX (CD42a) is a small membrane protein glycoprotein that forms a non-covalent complex with GP-Ib (CD42b)
- Actual binding site of vWF and thrombin is on CD42b
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Platelets and megakaryocytes
Negative staining
- Red blood cells, T cells
