CD Markers
CD42c
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD42c
CD42c
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2010
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD42c
Table of Contents
Definition / general | Diagrams / tables | Pathophysiology | Case reports | Uses by pathologists | Positive staining - normal | Additional referencesCite this page: Pernick N. CD42c. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd42c.html. Accessed January 15th, 2021.
Definition / general
- CD42a-d complex is receptor for von Willebrand factor and thrombin
- Also called platelet GPIb beta, glycoprotein Ib-beta
- Mutations are associated with Bernard-Soulier syndrome (giant platelet syndrome, OMIM #231200, Int J Hematol 2002;76:319), a bleeding disorder with thrombocytopenia, prolonged bleeding time and giant platelets
- Reduced levels are associated with bleeding disorders in AML patients (Saudi Med J 2005;26:1095)
Diagrams / tables
Images hosted on other servers:
CD42a-d complex
Pathophysiology
- CD42a-d complex is receptor for von Willebrand factor and thrombin
- GPIb alpha (CD42b) and GPIb beta (CD42c) form main part of VWF receptor
- CD42c also amplifies the platelet response to thrombin during platelet activation where thrombin is involved
- Platelet activation apparently involves disruption of the macromolecular complex of GP-Ib with the platelet glycoprotein IX (GP-IX) and dissociation of GP-Ib from the actin-binding protein
Case reports
- Mutation in Bernard-Soulier syndrome patient (J Thromb Haemost 2006;4:217)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Platelets and megakaryocytes
- Also endothelium, heart and brain (J Clin Invest 1994;93:2417)
Additional references
