CD Markers

Topic Completed: 1 October 2013

Minor changes: 2 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD45RB[title]

Related topics: CD45, CD45RO, CD45RA, CD45RC

Nat Pernick, M.D.
Page views in 2020: 923
Page views in 2021 to date: 36
Cite this page: Pernick N. CD45RB. website. Accessed January 16th, 2021.
Definition / general
  • CD45 isoform generated by alternative mRNA splicing of exon 5, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)
  • Influx of CD4+, CD45RB high T cells is present in inflammatory bowel disease; may be important in pathogenesis as they produce more proinflammatory cytokines than CD4+ CD45RB low T cells (J Leukoc Biol 2004;75:1010)
Diagrams / tables

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CD45RB expression changes during germinal center reaction

  • CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
  • CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
  • CD45 isoforms, including CD45RB, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule
  • Down regulated in memory cells
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Similar staining as CD45, except not expressed in Langerhans cells and some T cells
  • B cells, most T cells, monocytes, macrophages and granulocytes (weak)
Positive staining - disease
  • Most leukemias and lymphomas
Negative staining
  • Some T cells; Langerhans cells, platelets
  • Plasma cell neoplasms, Reed-Sternberg cells, some lymphoblastic lymphomas and some anaplastic large cell lymphomas
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