CD Markers
CD45RC
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD45RC[title]
Related topics: CD45, CD45RO, CD45RA, CD45RB
CD45RC
Author: Nat Pernick, M.D.
Topic Completed: 1 October 2013
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD45RC[title]
Related topics: CD45, CD45RO, CD45RA, CD45RB
Table of Contents
Definition / general | Pathophysiology | Uses by pathologists | Positive staining - normal | Negative stainingCite this page: Pernick N. CD45RC. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd45rc.html. Accessed January 15th, 2021.
Definition / general
- CD45 isoform generated by alternative mRNA splicing of exon 6, leading to change in the extracellular domain of the molecule (J Exp Med 1987;166:1548)
- Protein tyrosine phosphatase, receptor type C; PTPRC gene
- CD45RC+ CD4+ cells and CD45RC- CD4+ T cells have different cytokine profiles (Th1-like and Th2-like respectively)
- CD45RC expression divides human T cells into functionally distinct subsets that are imbalanced in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV); this may be a pre-existing immune abnormality involved in the etiology of AAV (PLoS One 2009;4:e5287)
- References: OMIM #151460
Pathophysiology
- CD45 is a high molecular weight transmembrane protein with intrinsic tyrosine phosphatase activity
- CD45 is heavily glycosylated, and expressed at high levels on nucleated hematopoietic cells
- CD45 isoforms, including CD45RC, are generated by alternative mRNA splicing of exons 4 (CD45RA), 5 (CD45RB) and 6 (CD45RC), leading to changes in the extracellular domain of the molecule
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Thymocytes, monocytes and dendritic cells
- High levels: B cells, NK and CD4+ T cells
- Intermediate levels: CD8+ T cells
Negative staining
- Myeloid cells
