CD Markers
CD48
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD48
CD48
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2010
Minor changes: 2 October 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: CD48
Table of Contents
Definition / general | Terminology | Pathophysiology | Clinical features | Uses by pathologists | Positive staining - normal | Negative staining | Additional referencesCite this page: Pernick N. CD48. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd48.html. Accessed January 15th, 2021.
Definition / general
- Activation associated cell surface glycoprotein active in lymphocytes
Terminology
- Also called B-lymphocyte activation marker Blast-1
Pathophysiology
- Glycosyl phosphatidylinositol (GPI) anchored surface molecule that mediates T cell activation by binding to CD2 ( J Immunol 2009;182:7672)
- Induces numerous effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils, partly based on its interaction with 2B4 / CD244 (Int J Biochem Cell Biol 2011;43:25)
- Regulates NK cell effector function (Blood 2006;107:3181)
Clinical features
- Mast cell response to M. tuberculosis is mediated by CD48 (J Immunol 2003;170:5590)
Uses by pathologists
- No significant clinical uses for pathologists
Positive staining - normal
- Lymphocytes, monocytes, granulocytes (weak)
Negative staining
- Platelets, fibroblasts, epithelium, endothelium; usually dendritic cells (J Immunol 2005;175:3690)
Additional references
