CD Markers

Topic Completed: 1 December 2010

Minor changes: 2 October 2020

Copyright: 2003-2021,, Inc.

PubMed Search: CD48

Nat Pernick, M.D.
Page views in 2020: 88
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Cite this page: Pernick N. CD48. website. Accessed January 15th, 2021.
Definition / general
  • Activation associated cell surface glycoprotein active in lymphocytes
  • Also called B-lymphocyte activation marker Blast-1
  • Glycosyl phosphatidylinositol (GPI) anchored surface molecule that mediates T cell activation by binding to CD2 ( J Immunol 2009;182:7672)
  • Induces numerous effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils, partly based on its interaction with 2B4 / CD244 (Int J Biochem Cell Biol 2011;43:25)
  • Regulates NK cell effector function (Blood 2006;107:3181)
Clinical features
Uses by pathologists
  • No significant clinical uses for pathologists
Positive staining - normal
  • Lymphocytes, monocytes, granulocytes (weak)
Negative staining
  • Platelets, fibroblasts, epithelium, endothelium; usually dendritic cells (J Immunol 2005;175:3690)
Additional references
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