CD Markers

Topic Completed: 1 December 2010

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD49

Related:   CD49bCD49cCD49d

Nat Pernick, M.D.
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Cite this page: Pernick N. CD49a. website. Accessed January 15th, 2021.
Definition / general
  • Integrin alpha 1 chain, which combines with beta1 subunit (CD29) to form a receptor for collagen and laminin
  • Also called very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain and ITGA1
  • Mesenchymal stem cells are selected from bone marrow by CD49+ with flow cytometry (Br J Haematol 2003;122:506, J Mol Histol 2007;38:449)
  • References: OMIM #192968
  • Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain; a given chain may combine with multiple partners resulting in different integrins
  • Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts and platelets
  • CD49a combines with beta1 subunit (CD29) to form a receptor for collagen and laminin; this receptor may also be involved in cell-cell adhesion and play a role in inflammation and fibrosis
  • CD49a contributes to beta cell functions important for pancreatic islet morphogenesis and glucose homeostasis (J Biol Chem 2004;279:53762)
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Activated B and T cells, monocytes, fibroblasts, platelets, endothelial cells and smooth muscle cells
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