CD Markers
CD49e
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD49e[TIAB] pathology "full text"[SB]
CD49e
Author: Nat Pernick, M.D.
Topic Completed: 1 December 2010
Minor changes: 18 September 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD49e[TIAB] pathology "full text"[SB]
Table of Contents
Definition / general | Terminology | Physiology | Clinical features | Uses by pathologists | Immunofluorescence images | Positive staining - normal | Additional referencesCite this page: Pernick N. CD49e. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd49e.html. Accessed January 15th, 2021.
Definition / general
- Fibronectin and fibrinogen receptor
Terminology
- Also called very late antigen (VLA) alpha 5 chain (VLA5), ITGA5, fibronectin receptor (FNRA)
Physiology
- Recognizes the sequence R-G-D in fibronectin and fibrinogen, mediating its adhesion function
Clinical features
- Important in wound reepithelialization (Larjava: Keratinocyte Interactions with Fibronectin During Wound Healing)
- Weakening of tumor cell adhesion strength, controlled by alpha5beta1, may mediate tumor cell motility (Mol Biol Cell 2005;16:51)
- Arginine-glycine-aspartic acid (RGD) sequence present on HIV Tat protein mediates vascular cell migration and invasion by binding to the alpha5beta1 and alphavbeta3 integrins, promotes angiogenesis and Kaposi sarcoma (Blood 1999;94:663)
- Persistently reduced expression of blood monocyte CD49e is an adverse prognostic marker in HIV (AIDS 2009;23:2247)
Uses by pathologists
- No significant clinical use by pathologists
Immunofluorescence images
Contributed by Dr. Vincent Achard
Peripheral blood monocytes and platelets (green is positive)
Negative control
Positive staining - normal
- T cells, early and activated B cells, platelets, monocytes, neutrophils
Additional references
