CD Markers
CD49f


Topic Completed: 1 December 2010

Minor changes: 18 September 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD49f[TI]

Nat Pernick, M.D.
Page views in 2020: 16
Page views in 2021 to date: 8
Cite this page: Pernick N. CD49f. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd49f.html. Accessed January 16th, 2021.
Definition / general
  • Forms laminin and thrombospondin receptors
Terminology
  • Also called very late antigen (VLA) alpha 6 chain (VLA6), ITGA6
Physiology
  • Forms laminin receptor on platelets (with CD29 / alpha6beta1) and on epithelial cells (with CD104 / alpha6beta4); alpha6beta1 is also part of the thrombospondin receptor (J Biol Chem 2003;278:40679)
  • Important for formation of hemidesmosomes on stratified squamous and transitional epithelia
Clinical features
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Epithelial cells, memory T cells, monocytes, platelets, megakaryocytes, thymocytes
Back to top
Image 01 Image 02