CD Markers
CD51
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD51
CD51
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD51
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD51. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd51.html. Accessed January 16th, 2021.
Definition / general
- Also called integrin alpha chain V or vitronectin receptor-alpha chain
- Integrins are membrane receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organization, cell proliferation, cell survival and differentiation
- Integrins are composed of an alpha chain and a beta chain
- Alpha-V integrins are a subset of integrins with a common alpha-V subunit combined with beta subunits 1, 3, 5, 6 or 8
- The beta chain of the vitronectin receptor is CD61
- Most alpha-V integrins recognize the RGD (Arg-Gly-Asp) sequence in various ligands such as vitronectin, fibronectin, osteopontin, bone sialoprotein, thrombospondin, fibrinogen, von Willebrand factor, tenascin or agrin
- Alpha V beta 3 integrin may mediate melanoma progression (Oncogene 2005;24:4710)
- CD51 on some dendritic cells serves as adenovirus receptor (J Leukoc Biol 2006;79:1271)
- OMIM #193210
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Endothelial cells, megakaryocytes, osteoclasts (Histochemistry 1991;96:169), monocytes and macrophages, placenta cytotrophoblast and Hofbauer cells (Acta Histochem 2003;105:253) and fibroblasts
Positive staining - disease
- Osteoclast disorders including osteoclast-like giant cell neoplasms (Mod Pathol 2006;19:161) and inflamed synovium (Ann Rheum Dis 1993;52:182)
Negative staining
- Cartilage (Ann Rheum Dis 2000;59:448)
