CD Markers

Topic Completed: 1 February 2002

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD51

Nat Pernick, M.D.
Page views in 2020: 125
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Cite this page: Pernick N. CD51. website. Accessed January 16th, 2021.
Definition / general
  • Also called integrin alpha chain V or vitronectin receptor-alpha chain
  • Integrins are membrane receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organization, cell proliferation, cell survival and differentiation
  • Integrins are composed of an alpha chain and a beta chain
  • Alpha-V integrins are a subset of integrins with a common alpha-V subunit combined with beta subunits 1, 3, 5, 6 or 8
  • The beta chain of the vitronectin receptor is CD61
  • Most alpha-V integrins recognize the RGD (Arg-Gly-Asp) sequence in various ligands such as vitronectin, fibronectin, osteopontin, bone sialoprotein, thrombospondin, fibrinogen, von Willebrand factor, tenascin or agrin
  • Alpha V beta 3 integrin may mediate melanoma progression (Oncogene 2005;24:4710)
  • CD51 on some dendritic cells serves as adenovirus receptor (J Leukoc Biol 2006;79:1271)
  • OMIM #193210
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Positive staining - disease
Negative staining
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