CD Markers
CD52



Topic Completed: 1 February 2002

Minor changes: 2 October 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD52[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD52. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd52.html. Accessed January 16th, 2021.
Definition / general
  • Also called Campath-1 and epididymal secretory protein E5
  • CD52 antibodies are lytic for target cells, both with human complement and via antibody dependent cellular cytotoxicity
  • References: OMIM #114280
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:

Fig 1A/B: normal tonsil shows lymphocytic staining, but there is no staining of connective tissue or vessels;
C: follicular lymphoma is CD52+; D: Reed-Sternberg cells (arrows) are CD52-


Fig 2A/B: SLL/CLL is CD52+; C: anaplastic lymphoma is CD52+; D: adult T cell leukemia/lymphoma is CD52+

Positive staining - normal
  • Thymocytes, lymphocytes, monocytes / macrophages, eosinophils, mast cells (Clin Lymphoma Myeloma 2006;6:478) and epithelial cells lining the male reproductive tract
Positive staining - disease
Negative staining
  • Neutrophils, Langerhans cells (normal), lymphocytes in paroxysmal nocturnal hemaglobinuria and Reed-Sternberg cells in Hodgkin’s lymphoma
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