CD Markers

Topic Completed: 1 February 2002

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD53

Nat Pernick, M.D.
Page views in 2020: 88
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Cite this page: Pernick N. CD53. website. Accessed January 16th, 2021.
Definition / general
  • Most specific and reliable pan-leukocyte marker
  • Encodes member of tetraspanin family, a cell surface protein with 4 hydrophobic domains that mediate signal transduction
  • Also has adhesion / activation functions
  • Upregulated in macrophages exposed to lipopolysaccharide (Mol Cells 2004;17:125)
  • May transduce CD2-generated signals in T cells and natural killer cells
  • May be a thymocyte selection marker, with CD69 (Int Immunol 2002;14:249)
  • Familial deficiency is associated with recurrent infectious diseases (Clin Diagn Lab Immunol 1997;4:229)
  • References: OMIM #151525
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
Positive staining - disease
  • Radioresistant tumor cells
Negative staining
  • Platelets, red blood cells and non-hematopoietic cells
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