CD Markers
CD53
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD53
CD53
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD53
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD53. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd53.html. Accessed January 16th, 2021.
Definition / general
- Most specific and reliable pan-leukocyte marker
- Encodes member of tetraspanin family, a cell surface protein with 4 hydrophobic domains that mediate signal transduction
- Also has adhesion / activation functions
- Upregulated in macrophages exposed to lipopolysaccharide (Mol Cells 2004;17:125)
- May transduce CD2-generated signals in T cells and natural killer cells
- May be a thymocyte selection marker, with CD69 (Int Immunol 2002;14:249)
- Familial deficiency is associated with recurrent infectious diseases (Clin Diagn Lab Immunol 1997;4:229)
- References: OMIM #151525
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Leukocytes; also dendritic cells, osteoclasts and osteoblasts and mesangial cells (Kidney Int 2003;63:534)
Positive staining - disease
- Radioresistant tumor cells
Negative staining
- Platelets, red blood cells and non-hematopoietic cells
