CD Markers
CD55
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD55[title]
CD55
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD55[title]
Table of Contents
Definition / general | Case reports | Uses by pathologists | Microscopic (histologic) images | Positive staining - normalCite this page: Pernick N. CD55. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd55.html. Accessed January 15th, 2021.
Definition / general
- Also called complement decay accelerating factor (DAF)
- Gene encodes Cromer blood group
- Binds C3bBb (alternative pathway convertase) and C4b2a (classical pathway convertase) to accelerate decay of the C3 convertases; protects against inappropriate complement activation (J Biol Chem 2005;280:2569)
- Receptor for CD97, echovirus (Proc Natl Acad Sci U S A 2002;99:10325) and Coxsackie B virus (J Virol 1998;72:9407)
- Also is part of lipopolysaccharide-induced receptor complex (Eur J Immunol 2003;33:1399)
- Genetic defects that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce paroxysmal nocturnal hemoglobinuria (PNH); also cause defective platelets, granulocytes, erythrocytes and possibly lymphocytes
- CD55 deficiency is common in patients treated with Campath (anti-CD52), which may predispose to PNH (Transplant Proc 2006;38:1750)
- A minor population of CD55-CD59 negative granulocytes and red blood cells predicts a good response to immunosuppressive therapy in patients with acquired aplastic anemia (Blood 2006;107:1308)
- Loss of CD55 is associated with poor prognosis in breast cancer (Clin Cancer Res 2004;10:2797); however high expression is associated with poor prognosis in colorectal carcinoma (Cancer Immunol Immunother 2003;52:638)
- References: OMIM #125240
Case reports
- Pregnant woman in her early 40's with thrombocytopenia due to PNH (Univ Pittsburgh Case #419)
Uses by pathologists
- Diagnosis of PNH (Am J Clin Pathol 2006;126:781)
Microscopic (histologic) images
Images hosted on other servers:
Breast carcinoma staining
Positive staining - normal
- All hematopoietic cells and all cell types in intimate contact with complement proteins
- Also epithelial cells lining extracellular compartments, body fluids and extracellular matrix
