CD Markers

Topic Completed: 1 February 2002

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD55[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD55. website. Accessed January 15th, 2021.
Definition / general
  • Also called complement decay accelerating factor (DAF)
  • Gene encodes Cromer blood group
  • Binds C3bBb (alternative pathway convertase) and C4b2a (classical pathway convertase) to accelerate decay of the C3 convertases; protects against inappropriate complement activation (J Biol Chem 2005;280:2569)
  • Receptor for CD97, echovirus (Proc Natl Acad Sci U S A 2002;99:10325) and Coxsackie B virus (J Virol 1998;72:9407)
  • Also is part of lipopolysaccharide-induced receptor complex (Eur J Immunol 2003;33:1399)
  • Genetic defects that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce paroxysmal nocturnal hemoglobinuria (PNH); also cause defective platelets, granulocytes, erythrocytes and possibly lymphocytes
  • CD55 deficiency is common in patients treated with Campath (anti-CD52), which may predispose to PNH (Transplant Proc 2006;38:1750)
  • A minor population of CD55-CD59 negative granulocytes and red blood cells predicts a good response to immunosuppressive therapy in patients with acquired aplastic anemia (Blood 2006;107:1308)
  • Loss of CD55 is associated with poor prognosis in breast cancer (Clin Cancer Res 2004;10:2797); however high expression is associated with poor prognosis in colorectal carcinoma (Cancer Immunol Immunother 2003;52:638)
  • References: OMIM #125240
Case reports
Uses by pathologists
Microscopic (histologic) images

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Breast carcinoma staining

Positive staining - normal
  • All hematopoietic cells and all cell types in intimate contact with complement proteins
  • Also epithelial cells lining extracellular compartments, body fluids and extracellular matrix
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