CD Markers
CD57



Topic Completed: 1 February 2011

Minor changes: 28 August 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: CD57[title] CD Marker

Nat Pernick, M.D.
Page views in 2019: 4,607
Page views in 2020 to date: 3,763
Cite this page: Pernick N. CD57. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd57.html. Accessed October 29th, 2020.
Definition / general
  • Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
  • Glycoprotein with cell adhesion functions
  • May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
  • References: OMIM #151290
Case reports
Uses by pathologists
  • Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Large granular lymphocytic leukemia (fig 11)

Missing Image

Papillary carcinoma of thyroid (fig B)

Missing Image

"Atypical cytology, cannot exclude papillary carcinoma"
(fig B)

Positive staining - normal
  • NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive staining - disease
Positive staining - tumors
Negative staining
  • B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor
Back to top
Image 01 Image 02