CD Markers
CD58
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD58[title]
CD58
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD58[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD58. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd58.html. Accessed January 15th, 2021.
Definition / general
- Also called LFA-3 (lymphocyte function associated antigen)
- Ligand for CD2 (J Mol Biol 2001;312:711)
- Mediates adhesion between NK cells and target cells (J Immunol 2003;170:294), antigen presenting cells and T cells (Cell 1999;97:791), thymocytes and thymic epithelial cells
- High serum levels in Hepatitis B, associated with liver cell damage (World J Gastroenterol 2006;12:4237)
- References: OMIM #153420
Uses by pathologists
- Detect minimal residual disease in pre-B ALL (Haematologica 2003;88:1245)
Microscopic (histologic) images
Images hosted on other servers:
Buccal mucosa:
stratified squamous
epithelium (LFA-3+)
Cardiac muscle:
intercalated discs
and capillary
endothelium (LFA-3+)
Cerebellum: cortical microglia (A, LFA-3+); liver: Kupffer cells (B, LFA-3+); skin: epidermal dendritic cell (C, LFA-3 +)
Kidney: proximal tubule (LFA-3+, p) and distal tubule (d) epithelial cells with central, spherical nuclei (LFA-3 negative)
Testis: cells close to seminiferous tubule boundary, reminiscent of Sertoli cells
Positive staining - normal
- Leukocytes (but not mature B cells), pre B cells, erythrocytes, endothelial cells, epithelial cells, fibroblasts and cardiac muscle (J Clin Pathol 1990;43:893)
Positive staining - disease
- Pre-B ALL (Am J Clin Pathol 2005;123:119)
Negative staining
- Mature B cells
