CD Markers

Topic Completed: 1 August 2013

Minor changes: 1 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD6

Nat Pernick, M.D.
Page views in 2020: 136
Page views in 2021 to date: 4
Cite this page: Pernick N. CD6. website. Accessed January 15th, 2021.
Definition / general
  • Adhesion molecule mediating binding of developing thymocytes with thymic epithelial cells (OMIM #186720)
  • Belongs to ancient scavenger receptor superfamily; at #11q13
  • Also called T cell differentiation antigen, T12
  • Essential for stable contact between T cells and antigen presenting cells, which leads to T cell proliferation (Blood 2006;107:3212)
  • Binds to CD166 (ALCAM)
  • Monomeric 105 or 130kD membrane glycoprotein; size difference is due to differences in phosphorylation (Eur J Immunol 1995;25:2765)
  • May be signaling attenuator whose expression alone is sufficient to restrain signaling in T cells (Eur J Immunol 2012;42:195)
Clinical features
Uses by pathologists
  • No significant clinical use by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Brain (CD6-)

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Kidney (CD6-)

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Skeletal muscle (CD6-)

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Uterus (CD6-)

Positive staining - normal
  • Mature T cells, B cell subset (B1 cells), NK cells (subset, J Innate Immun 2011;3:420), CNS cells
  • High levels on mature (medullary) thymocytes, low levels on immature (cortical) thymocytes
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