CD Markers
CD61
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: CD61[title]
CD61
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 14 May 2021
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: CD61[title]
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD61. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd61.html. Accessed June 10th, 2023.
Definition / general
- Also called integrin beta 3 chain (ITGB3)
- Combines with CD41 (integrin alpha IIb) to form platelet glycoprotein IIb/IIIa, a receptor for fibrinogen, fibronectin, plasminogen, prothrombin, thrombospondin, vitronectin and von Willebrand factor
- Combines with CD51 to form receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor
- CD51-CD61 is present on endothelium, endothelial cells, smooth muscle, some B cells, monocytes, macrophages, platelets, osteoclasts, mast cells, fibroblasts and tumor cells
- Platelet activation causes a conformation change in GPIIb/IIIa, enabling the binding of soluble fibrinogen and forming a platelet plug
- CD61 defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease
- CD61 has role in pathogenesis of asthma (Am J Respir Crit Care Med 2005;172:67)
- Polymorphisms may cause premature coronary artery disease (Arch Pathol Lab Med 1999;123:1223)
- High pre-kidney transplant levels associated with acute rejection (Transplant Proc 2003;35:1360)
- References: J Clin Invest 2005;115:3363 (review), OMIM #173470
Uses by pathologists
- Identify platelets, megakaryocytes and platelet thrombi
- Distinguish TTP (diffuse CD61+ platelet rich thrombi) from DIC (no / sparse thrombi, Cardiovasc Pathol 2005;14:150)
- Count platelets in thrombocytopenic patients (Br J Haematol 2001;112:584)
Microscopic (histologic) images
Images hosted on other servers:
AML-M7
Positive staining - normal
- Platelets, megakaryocytes, myeloid progenitor cells and endothelial cells
Positive staining - disease
- AML M7, AML M6 (some) and blasts in transient myeloproliferative disorder (Am J Clin Pathol 2001;116:204)
Negative staining
- AML M0-M5, M6 (most)
