CD Markers

Last author update: 1 February 2002
Last staff update: 14 May 2021

Copyright: 2002-2023,, Inc.

PubMed Search: CD61[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD61. website. Accessed June 10th, 2023.
Definition / general
  • Also called integrin beta 3 chain (ITGB3)
  • Combines with CD41 (integrin alpha IIb) to form platelet glycoprotein IIb/IIIa, a receptor for fibrinogen, fibronectin, plasminogen, prothrombin, thrombospondin, vitronectin and von Willebrand factor
  • Combines with CD51 to form receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor
  • CD51-CD61 is present on endothelium, endothelial cells, smooth muscle, some B cells, monocytes, macrophages, platelets, osteoclasts, mast cells, fibroblasts and tumor cells
  • Platelet activation causes a conformation change in GPIIb/IIIa, enabling the binding of soluble fibrinogen and forming a platelet plug
  • CD61 defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease
  • CD61 has role in pathogenesis of asthma (Am J Respir Crit Care Med 2005;172:67)
  • Polymorphisms may cause premature coronary artery disease (Arch Pathol Lab Med 1999;123:1223)
  • High pre-kidney transplant levels associated with acute rejection (Transplant Proc 2003;35:1360)
  • References: J Clin Invest 2005;115:3363 (review), OMIM #173470
Uses by pathologists
Microscopic (histologic) images

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Positive staining - normal
  • Platelets, megakaryocytes, myeloid progenitor cells and endothelial cells
Positive staining - disease
Negative staining
  • AML M0-M5, M6 (most)
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