CD Markers
CD64
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD64[title]
CD64
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 2 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD64[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD64. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd64.html. Accessed January 15th, 2021.
Definition / general
- Also called Fc gamma RI, CD64A
- High affinity receptor binds to Fc region of IgG
- Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes
- Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates
- Also binds to C reaction protein and mediates its effects (J Biol Chem 2005;280:25095)
- Denge fever immune complexes enter macrophages via CD64 (J Virol 2006;80:10128)
- References: OMIM #146760
Uses by pathologists
- High neutrophil CD64 levels predict sepsis (Arch Pathol Lab Med 2006;130:654, Lab Hematol 2005;11:137), early onset of infection in neonates (Pediatr Res 2004;56:796) and infection in rheumatoid arthritis patients (J Rheumatol 2006;33:2416)
Positive staining - normal
- Antigen presenting cells including macrophages / monocytes, activated granulocytes and dendritic cells; also early myeloid cells
Positive staining - disease
- AML M3 (usually); M4, M5 (Am J Clin Pathol 1998;110:797), M0-M2 (variable)
Negative staining
- AML M7
