CD Markers

Topic Completed: 1 February 2002

Minor changes: 2 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD64[title]

Nat Pernick, M.D.
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Cite this page: Pernick N. CD64. website. Accessed March 6th, 2021.
Definition / general
  • Also called Fc gamma RI, CD64A
  • High affinity receptor binds to Fc region of IgG
  • Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes
  • Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates
  • Also binds to C reaction protein and mediates its effects (J Biol Chem 2005;280:25095)
  • Denge fever immune complexes enter macrophages via CD64 (J Virol 2006;80:10128)
  • References: OMIM #146760
Uses by pathologists
Positive staining - normal
  • Antigen presenting cells including macrophages / monocytes, activated granulocytes and dendritic cells; also early myeloid cells
Positive staining - disease
Negative staining
  • AML M7
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