Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD66. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd66.html. Accessed April 15th, 2021.
Definition / general
- Also called CEACAM1, biliary glycoprotein, BGP, C-CAM, CD66A
- Primordial protein of carcinoembryonic antigen (CEA) family
- Cell adhesion molecule capable of activating neutrophils
- Receptor for Neisseria gonorrhoeae and N. meningitides; binding prevents epithelial detachment, a defense mechanism that hinders colonization (J Cell Biol 2005;170:825); CD66a+ B cells are also killed by N. gonorrhoeae (Infect Immun 2005;73:4171)
- With osteopontin, may mediate invasion of extravillous trophoblast at maternal-fetal interface (J Clin Endocrinol Metab 2005;90:5407)
- Interactions with CEA inhibit NK cell cytotoxicity (J Immunol 2005;174:6692)
- Downregulated in breast (J Histochem Cytochem 1997;45:957), colorectal, endometrial, hepatocellular, prostate (particularly Gleason grade 4/5, Hum Pathol 2002;33:290) and renal cell carcinoma (J Pathol 2004;204:258)
- References: OMIM #109770
Uses by pathologists
- Expression predicts metastases in cutaneous melanoma (J Clin Oncol 2002;20:2530)
Microscopic (histologic) images
Positive staining - normal
- Granulocytes, lymphocytes, epithelial cells, endothelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells, extravillous trophoblast (Am J Pathol 2000;156:1165)
Positive staining - disease
- Low grade prostate carcinoma
Negative staining
- High grade (Gleason 4/5) prostate carcinoma