Pathology Outlines

CD Markers
CD66

Author: Nat Pernick, M.D.

Topic Completed: 1 November 2014

Minor changes: 8 October 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: CD66

Page views in 2020: 1,250

Page views in 2021 to date: 200

Table of Contents

Cite this page: Pernick N. CD66. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd66.html. Accessed April 15th, 2021.

Definition / general

Also called CEACAM1, biliary glycoprotein, BGP, C-CAM, CD66A
Primordial protein of carcinoembryonic antigen (CEA) family
Cell adhesion molecule capable of activating neutrophils
Receptor for Neisseria gonorrhoeae and N. meningitides; binding prevents epithelial detachment, a defense mechanism that hinders colonization (J Cell Biol 2005;170:825); CD66a+ B cells are also killed by N. gonorrhoeae (Infect Immun 2005;73:4171)
With osteopontin, may mediate invasion of extravillous trophoblast at maternal-fetal interface (J Clin Endocrinol Metab 2005;90:5407)
Interactions with CEA inhibit NK cell cytotoxicity (J Immunol 2005;174:6692)
Downregulated in breast (J Histochem Cytochem 1997;45:957), colorectal, endometrial, hepatocellular, prostate (particularly Gleason grade 4/5, Hum Pathol 2002;33:290) and renal cell carcinoma (J Pathol 2004;204:258)
References: OMIM #109770

Uses by pathologists

Expression predicts metastases in cutaneous melanoma (J Clin Oncol 2002;20:2530)

Microscopic (histologic) images

Images hosted on other servers:

Colon

Expression at maternal-fetal surface

Various breast lesions (Figure 1)

Positive staining - normal

Granulocytes, lymphocytes, epithelial cells, endothelial cells, prostate glands and ducts (dense), bile canaliculi between liver cells, extravillous trophoblast (Am J Pathol 2000;156:1165)

Positive staining - disease

Low grade prostate carcinoma

Negative staining

High grade (Gleason 4/5) prostate carcinoma