CD Markers
CD66f
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: pregnancy-specific beta-1 glycoprotein
CD66f
Author: Nat Pernick, M.D.
Topic Completed: 1 November 2014
Minor changes: 6 November 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: pregnancy-specific beta-1 glycoprotein
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CD66f. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd66f.html. Accessed January 16th, 2021.
Definition / general
- Also called pregnancy-specific beta-1 glycoprotein, PSG1
- May be involved in immune regulation, protection of fetus from maternal immune system
- Released into maternal circulation during pregnancy
- Low levels in maternal blood predict spontaneous abortion
- References: OMIM #176390
Uses by pathologists
- No significant clinical use by pathologists
Microscopic (histologic) images
Images hosted on other servers:
Implanted ovum (CD66f+, syncytiotrophoblast)
Normal placenta (CD66f+, trophoblast)
Hydatidiform mole (syncytiotrophoblast)
Invasive mole (CD66f+, large trophoblast cells)
Choriocarcinoma of uterus
(CD66f+, syncytiotrophoblast);
note absence of staining in
cytotrophoblast
Positive staining - normal
- Syncytiotrophoblasts, fetal liver and myeloid cells
Positive staining - disease
- Hydatidiform and invasive moles, choriocarcinoma (J Clin Pathol 1977;30:19)
