Stains & CD markers
CD70-79
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD72[title], CD73[title], CD74[title], CD75, CD75s, CD77, CDw78
CD70-79
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 24 June 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD72[title], CD73[title], CD74[title], CD75, CD75s, CD77, CDw78
Table of Contents
CD70 | CD71 | CD72 | CD73 | CD74 | CD75 | CD75s / CDw76 | CD77 | CDw78 | CD79a | CD79b | Microscopic (histologic) imagesCite this page: Pernick N. CD70-79. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd70to79.html. Accessed April 23rd, 2024.
CD70
- See CD70
CD71
- See CD71
CD72
- Cell surface protein expressed exclusively on B cells
- Regulates mature B cell differentiation, prevents differentiation of naive B cells into plasma cells (Eur J Immunol 2005;35:2325)
- Ligand of CD5 and CD100 (J Immunol 1992;148:1630, Int Immunol 2005;17:1277)
- Not the same as DBA.44 (abstract in the following article is apparently wrong) (Am J Surg Pathol 1996;20:613)
- Increased nucleotide mutation of CD72 mRNA accounts for decreased CD72 expression in B cells of teenage SLE patients (Pediatr Allergy Immunol 2006;17:565)
- Uses by pathologists: marker of B cells (not commonly used)
- Positive staining - normal: B cells only
- Positive staining - disease: B cell lymphoma
- Negative staining: plasma cells (Am J Hematol 1992;41:151)
- Reference: OMIM: 107272 [Accessed 4 May 2021]
CD73
- Also called ecto-5'-nucleotidase
- Catalyzes dephosphorylation of ribo and deoxyribonucleotides to their corresponding nucleosides, such as 5’ AMP to adenosine
- Mediates costimulatory signals in T cell activation
- Mediates lymphocyte adhesion to dendritic cells and endothelium (Blood 1996;88:1755, J Immunol 2000;165:5411)
- May protect against vascular inflammation and neointima formation (Circulation 2006;113:2120)
- May be a lymphocyte maturation marker
- No significant clinical use by pathologists
- Positive staining - normal: B and T cell subset, endothelial cells, follicular dendritic cells and epithelial cells
- Reference: OMIM: 129190 [Accessed 4 May 2021]
CD74
- Also called LN2, HLA-DR associated invariant chain
- Gamma chain antigen associated with MHC class II antigen and antigen presentation
- MHC class II chaperone stabilizes alpha / beta heterodimers in a complex soon after synthesis and directs transport of the complex from the endoplasmic reticulum to compartments, where peptide loading of class II takes place
- H. pylori urease binds to CD74 on gastric epithelial cells and upregulates CD74 expression (Infect Immun 2006;74:1148, J Immunol 2005;175:171)
- Has important role in mucosal immunity
- Receptor for macrophage migration inhibitory factor, a proinflammatory cytokine (J Immunol 2006;177:8730)
- Associated with perineural invasion in pancreatic carcinoma (Clin Cancer Res 2006;12:2419)
- Uses by pathologists: B cell marker (not commonly used)
- Positive staining - normal: B cells, activated T cells, macrophages, interdigitating dendritic cells, activated endothelial and epithelial cells
- Positive staining - disease:
- Many B cell lymphomas, myeloma (Clin Cancer Res 2004;10:6606)
- Some T cell lymphomas, Reed-Sternberg cells, many myeloid leukemias and Langerhans cell histiocytosis
- Renal clear cell and chromophobe carcinoma (most) (Am J Pathol 2001;158:1639)
- Negatie staining: renal oncocytoma
- Reference: OMIM: 142790 [Accessed 5 May 2021]
CD75
- Also called lactosamines, LN1; formerly CDw75
- Carbohydrate, not a protein (Cell 1992;68:1003)
- Ligand for CD22 (Cell 1991;66:1133)
- A neuraminidase sensitive lymphocyte cell surface differentiation antigen
- Strong expression associated with better prognosis in follicular center cell lymphoma (J Pathol 2006;209:352)
- Uses by pathologists: marker of follicular center cell lymphoma; identify Reed-Sternberg cells (not commonly used)
- Positive staining - normal: mature B cells (germinal center derivation), erythrocytes, some T cells and some epithelial cells
- Positive staining - disease: popcorn cells of lymphocyte predominance Hodgkin’s lymphoma, many B cell lymphomas (Histopathology 1999;35:209)
- Reference: Arch Pathol Lab Med 2002;126:862
CD75s / CDw76
- CDw76 renamed CD75s at 7th HLDA Workshop
- Alpha 2, 6 sialylated lactosamines
- A carbohydrate, not a protein
- Marker of murine CD8+ suppressor T cells (Int Immunol 2003;15:1389)
- No significant clinical use by pathologists
- Positive staining - normal: B cells, some T cells
CD77
- Also called globotriaosylceramide, CD77 synthase (OMIM: 607922 [Accessed 5 May 2021])
- pK blood group antigen on erythrocytes
- Carbohydrate, not a protein
- Endothelial receptor for verotoxins from Shigella dysenteriae and E. coli (J Biol Chem 2006;281:10230)
- Also expressed by liver flukes (Biol Chem 2001;382:195)
- Interacts with CD19 (J Cell Physiol 1998;176:281)
- Mediates apoptosis of renal vascular endothelial cells and intestinal epithelial cells, resulting in hemolytic uremic syndrome
- Does not discriminate centroblasts from centrocytes
- Uses by pathologists: identify germinal center cells
- Positive staining - normal:
- B cells (centrocytes, centroblasts, plasmablasts) (J Immunol 2006;177:4341)
- Megakaryoblasts and platelets (J Biol Chem 2002;277:11247)
- Positive staining - disease: Burkitt's lymphoma
CDw78
- Deleted at 7th HLDA Workshop (reasons unknown)
- Defines a conformation of MHC class II molecules bound to peptides acquired through trafficking to lysosomal antigen processing compartments and not MHC class II molecules associated with tetraspanins (J Immunol 2006;177:5451)
- Appears on B cells following HLA-DR and preceding CD10, CD19, CD22 and CD37
- No significant clinical use by pathologists
- Positive staining - normal: B cells
CD79a
- See CD79a
CD79b
- See CD79b
Microscopic (histologic) images
Images hosted on other servers:
CD74: renal tumors (figs D-F)
CD74: multiple myelomas
(figs G-J)
CD74: increased expression in H. pylori+ epithelium
CD75: marginal zone lymphoma (aberrant expression)
