CD Markers
CD70-79



Topic Completed: 1 February 2002

Minor changes: 14 May 2021

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: CD72[title], CD73[title], CD74[title], CD75, CD75s, CD77, CDw78

Nat Pernick, M.D.
Page views in 2021 to date: 225
Cite this page: Pernick N. CD70-79. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd70to79.html. Accessed June 20th, 2021.
CD70
CD71
CD72
CD73
  • Also called ecto-5'-nucleotidase
  • Catalyzes dephosphorylation of ribo and deoxyribonucleotides to their corresponding nucleosides, such as 5’ AMP to adenosine
  • Mediates costimulatory signals in T cell activation
  • Mediates lymphocyte adhesion to dendritic cells and endothelium (Blood 1996;88:1755, J Immunol 2000;165:5411)
  • May protect against vascular inflammation and neointima formation (Circulation 2006;113:2120)
  • May be a lymphocyte maturation marker
  • No significant clinical use by pathologists
  • Positive staining - normal: B and T cell subset, endothelial cells, follicular dendritic cells and epithelial cells
  • Reference: OMIM: 129190 [Accessed 4 May 2021]
CD74
  • Also called LN2, HLA-DR associated invariant chain
  • Gamma chain antigen associated with MHC class II antigen and antigen presentation
  • MHC class II chaperone stabilizes alpha / beta heterodimers in a complex soon after synthesis and directs transport of the complex from the endoplasmic reticulum to compartments, where peptide loading of class II takes place
  • H. pylori urease binds to CD74 on gastric epithelial cells and upregulates CD74 expression (Infect Immun 2006;74:1148, J Immunol 2005;175:171)
  • Has important role in mucosal immunity
  • Receptor for macrophage migration inhibitory factor, a proinflammatory cytokine (J Immunol 2006;177:8730)
  • Associated with perineural invasion in pancreatic carcinoma (Clin Cancer Res 2006;12:2419)
  • Uses by pathologists: B cell marker (not commonly used)
  • Positive staining - normal: B cells, activated T cells, macrophages, interdigitating dendritic cells, activated endothelial and epithelial cells
  • Positive staining - disease:
  • Negatie staining: renal oncocytoma
  • Reference: OMIM: 142790 [Accessed 5 May 2021]
CD75
  • Also called lactosamines, LN1; formerly CDw75
  • Carbohydrate, not a protein (Cell 1992;68:1003)
  • Ligand for CD22 (Cell 1991;66:1133)
  • A neuraminidase sensitive lymphocyte cell surface differentiation antigen
  • Strong expression associated with better prognosis in follicular center cell lymphoma (J Pathol 2006;209:352)
  • Uses by pathologists: marker of follicular center cell lymphoma; identify Reed-Sternberg cells (not commonly used)
  • Positive staining - normal: mature B cells (germinal center derivation), erythrocytes, some T cells and some epithelial cells
  • Positive staining - disease: popcorn cells of lymphocyte predominance Hodgkin’s lymphoma, many B cell lymphomas (Histopathology 1999;35:209)
  • Reference: Arch Pathol Lab Med 2002;126:862
CD75s / CDw76
  • CDw76 renamed CD75s at 7th HLDA Workshop
  • Alpha 2, 6 sialylated lactosamines
  • A carbohydrate, not a protein
  • Marker of murine CD8+ suppressor T cells (Int Immunol 2003;15:1389)
  • No significant clinical use by pathologists
  • Positive staining - normal: B cells, some T cells
CD77
  • Also called globotriaosylceramide, CD77 synthase (OMIM: 607922 [Accessed 5 May 2021])
  • pK blood group antigen on erythrocytes
  • Carbohydrate, not a protein
  • Endothelial receptor for verotoxins from Shigella dysenteriae and E. coli (J Biol Chem 2006;281:10230)
  • Also expressed by liver flukes (Biol Chem 2001;382:195)
  • Interacts with CD19 (J Cell Physiol 1998;176:281)
  • Mediates apoptosis of renal vascular endothelial cells and intestinal epithelial cells, resulting in hemolytic uremic syndrome
  • Does not discriminate centroblasts from centrocytes
  • Uses by pathologists: identify germinal center cells
  • Positive staining - normal:
  • Positive staining - disease: Burkitt's lymphoma
CDw78
  • Deleted at 7th HLDA Workshop (reasons unknown)
  • Defines a conformation of MHC class II molecules bound to peptides acquired through trafficking to lysosomal antigen processing compartments and not MHC class II molecules associated with tetraspanins (J Immunol 2006;177:5451)
  • Appears on B cells following HLA-DR and preceding CD10, CD19, CD22 and CD37
  • No significant clinical use by pathologists
  • Positive staining - normal: B cells
CD79a
CD79b
Microscopic (histologic) images

Images hosted on other servers:
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CD74: renal tumors (figs D-F)

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CD74: multiple myelomas
(figs G-J)

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CD74: increased expression in H. pylori+ epithelium

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CD75: marginal zone lymphoma (aberrant expression)

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