CD Markers
CD72
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD72[title]
CD72
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 8 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD72[title]
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD72. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd72.html. Accessed January 16th, 2021.
Definition / general
- Cell surface protein expressed exclusively on B cells
- Regulates mature B cell differentiation, prevents differentiation of naive B cells into plasma cells (Eur J Immunol 2005;35:2325)
- Ligand of CD5 (J Immunol 1992;148:1630) and CD100 (Int Immunol 2005;17:1277)
- Not the same as DBA.44 (abstract in Am J Surg Pathol 1996;20:613 is apparently wrong)
- Increased nucleotide mutation of CD72 mRNA accounts for decreased CD72 expression in B cells of teenage SLE patients (Pediatr Allergy Immunol 2006;17:565)
- References: OMIM #107272
Uses by pathologists
- Marker of B cells (not commonly used)
Positive staining - normal
- B cells only
Positive staining - disease
- B cell lymphoma
Negative staining
- Plasma cells (Am J Hematol 1992;41:151)
