CD Markers
CD75
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD75
Related topics: CD75s
CD75
Author: Nat Pernick, M.D.
Topic Completed: 1 February 2002
Minor changes: 8 October 2020
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: CD75
Related topics: CD75s
Table of Contents
Definition / general | Uses by pathologists | Microscopic (histologic) images | Positive staining - normal | Positive staining - diseaseCite this page: Pernick N. CD75. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd75.html. Accessed January 16th, 2021.
Definition / general
- Also called lactosamines, LN-1; formerly CDw75
- A carbohydrate, not a protein (Cell 1992;68:1003)
- Ligand for CD22 (Cell 1991;66:1133)
- A neuraminidase-sensitive lymphocyte cell surface differentiation antigen
- Strong expression associated with better prognosis in follicular center cell lymphoma (J Pathol 2006;209:352)
- References: Arch Pathol Lab Med 2002;126:862
Uses by pathologists
- Marker of follicular center cell lymphoma; identify Reed-Sternberg cells (not commonly used)
Microscopic (histologic) images
Images hosted on other servers:
Marginal zone lymphoma (aberrant expression)
Positive staining - normal
- Mature B cells (germinal center derivation), erythrocytes, some T cells and some epithelial cells
Positive staining - disease
- "Popcorn cells" of lymphocyte predominance Hodgkin’s lymphoma, many B cell lymphomas (Histopathology 1999;35:209)
