CD Markers

Topic Completed: 1 February 2002

Minor changes: 9 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD77

Nat Pernick, M.D.
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Cite this page: Pernick N. CD77. website. Accessed January 15th, 2021.
Definition / general
  • Also called globotriaosylceramide, CD77 synthase (OMIM #607922)
  • pK blood group antigen on erythrocytes
  • A carbohydrate, not a protein
  • Endothelial receptor for verotoxins (J Biol Chem 2006;281:10230) from Shigella dysenteriae and E. coli
  • Also expressed by liver flukes (Biol Chem 2001;382:195)
  • Interacts with CD19 (J Cell Physiol 1998;176:281)
  • Mediates apoptosis of renal vascular endothelial cells and intestinal epithelial cells, resulting in hemolytic uremic syndrome
  • Does NOT discriminate centroblasts from centrocytes
Uses by pathologists
  • Identify germinal center cells
Positive staining - normal
Positive staining - disease
  • Burkitt's lymphoma
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