CD Markers
CD79b
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD79b[title]
See Also: CD79a
CD79b
Author: Nat Pernick, M.D.
Last author update: 1 February 2002
Last staff update: 14 May 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: CD79b[title]
See Also: CD79a
Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Negative stainingCite this page: Pernick N. CD79b. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd79b.html. Accessed April 25th, 2024.
Definition / general
- Also called B29, B cell antigen receptor complex associated protein beta-chain
- Encodes the Ig-beta protein of the B cell antigen receptor; the receptor also includes Ig-alpha protein (CD79a) and surface immunoglobulin
- First expressed in cells with Ig µ chains and remains expressed throughout B cell differentiation to plasma cells
- References: OMIM #147245
Uses by pathologists
- Distinguish CLL from other B cell disorders if intensity of staining is considered (J Clin Pathol 2002;55:180)
Positive staining - normal
- B cells, plasma cells
Positive staining - disease
- B cell lymphoma and lymphoproliferative disorders: CLL (18%, Arch Pathol Lab Med 2003;127:561), CLL with IgM paraproteins (58%, Am J Clin Pathol 2005;123:594) and lymphoplasmacytic lymphoma (85%, Am J Clin Pathol 2005;124:414)
Negative staining
- Hairy cell leukemia (usually)
